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レポートナンバー 0000036794

哺乳類細胞発酵技術の世界市場規模調査・予測:タイプ別、用途別、最終用途別、おび地域別の分析(2023年〜2030年)

Bizwit Research & Consulting LLP

Global Mammalian Cell Fermentation Technology Market Size Study & Forecast, by Type (Hamster Ovary (CHO) Cell Fermentation, Human Embryonic Kidney (HEK) Cell Fermentation, Baby Hamster Kidney (BHK) Cell Fermentation, Murine Myeloma Cell Fermentation, Others), By Application (Monoclonal Antibodies, Recombinant Proteins, Vaccines, Hormones, Enzymes and Others), By End-use (Biopharmaceutical Companies, CMOs & CDMOs, Academic & Research Institutes) and Regional Analysis, 2023-2030

発刊日 2023/10/20

言語英語

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レポート概要

世界の哺乳類細胞発酵技術市場は、2022年に約394億9,000万米ドルと評価され、予測期間の203年から2030年には8.64%以上の成長率で成長すると予測されています。哺乳類細胞発酵は、様々なバイオシミラー、酵素、ワクチン、その他の生物製剤の製造に広く利用されており、バイオ医薬品の開発には欠かせないステップです。哺乳動物細胞は、幹細胞から試験管内で生産された後、発酵のためにバイオリアクターで培養されます。この過程で、細胞は様々な代謝経路を用いて必須製品別を生産します。哺乳類細胞発酵技術の市場は、慢性疾患の有病率の増加、新規かつ安全な治療法に対するニーズの高まり、生物製剤やバイオシミラーに対する需要の高まりといった要因によって牽引されています。

さらに、がん治療にはモノクローナル抗体、治療用タンパク質、ワクチンなどの生物製剤の使用が多く含まれることから、がんを含む様々な慢性疾患の有病率の上昇が市場成長の原動力となっています。哺乳類細胞発酵は、これらの複雑な生物製剤を生産するための重要な方法です。生物製剤の需要は、がんの有病率の上昇により上昇し、それが哺乳類細胞発酵技術の必要性を後押ししています。国際がん研究機関(IARC)によると、2021年には約190万件の新規症例が記録され、2040年には2,750万件の新規症例になると予測されています。生物製剤とバイオシミラーの需要が哺乳類細胞発酵技術市場を牽引しています。これらの治療法は、がん、自己免疫疾患、様々な慢性疾患など、多くの疾患への対応に不可欠です。2022年5月、Biocon Biologics Ltd.社とViatris Inc社.は、Roche社のAvastin(ベバシズマブ)のバイオシミラーであるAbevmy(ベバシズマブ)について、4つのがん適応症にわたってカナダ保健省から承認を取得しました。その結果、生物製剤とバイオシミラーの開拓が進み、市場成長の原動力となっています。さらに、技術の進歩や製薬企業による研究開発費の増加が、市場に新たな機会をもたらしています。しかし、技術開拓に伴う高コストが、予測期間の2023年から2030年の市場成長を抑制しています。

世界の哺乳類細胞発酵技術市場調査の対象となる主要地域には、アジア太平洋、北アメリカ、ヨーロッパ、ラテンアメリカ、中東・アフリカが含まれます。北アメリカは、バイオ医薬品産業の存在感が強く、政府の規制が後押しし、医療インフラが整備されていることから、2022年の市場シェアは最大で、市場を独占しました。さらに、生物製剤やバイオシミラーに対する需要の増加、慢性疾患の有病率の上昇が、同地域の市場拡大に寄与しています。アジア太平洋は、患者数の多さ、生物学的製剤に対する需要の増加、バイオテクノロジー研究開発を支援する政府の取り組み、製造受託機関(CMO)の増加などの要因により、予測期間中に最も急成長する地域となる見込みです。

調査範囲

  • 調査企業
    ➣ Thermo Fisher Scientific, Inc.
    ➣ Merck KGaA
    ➣ Danaher Corporation
    ➣ Lonza Group
    ➣ Hoffmann-La Roche Ltd
    ➣ Sartorius AG
    ➣ AstraZeneca
    ➣ Bristol-Myers Squibb
    ➣ Amgen Inc.
    ➣ Gilead Sciences Inc.

調査範囲

  • 調査対象年
    ➣ 実績データ - 2020 - 2021
    ➣ 推定基準年 - 2022
    ➣ 予測期間 - 2023-2030

この調査の目的は、近年のさまざまなセグメントおよび国の市場規模を定義し、今後数年間の市場規模を予測することです。この報告書は、調査に参加している国の業界の定性的および定量的側面の両方を組み込むように設計されています。

このレポートは、市場の将来の成長を定義する推進要因や課題などの重要な側面に関する詳細情報も提供します。さらに、競争環境と主要企業の製品提供の詳細な分析とともに、利害関係者が投資できるミクロ市場における潜在的な機会も組み込まれています。

  • 市場セグメント
    ➣ タイプ別
      ◇ ハムスター卵巣(CHO)細胞発酵
      ◇ ヒト胚性腎臓(HEK)細胞発酵
      ◇ ベビーハムスター腎臓(BHK)細胞発酵
      ◇ マウス骨髄腫細胞発酵
      ◇ その他
    ➣ 用途別
      ◇ モノクローナル抗体
      ◇ 組み換えタンパク質
      ◇ ワクチン
      ◇ ホルモン
      ◇ 酵素
      ◇ その他
    ➣ 最終用途別
      ◇ バイオ医薬品企業
      ◇ CMOおよびCDMO
      ◇ 学術・研究機関
    ➣ 地域別
       ◇ 北アメリカ
       ✓ アメリカ
       ✓ カナダ
       ◇ ヨーロッパ
       ✓ イギリス
       ✓ ドイツ
       ✓ フランス
       ✓ スペイン
       ✓ イタリア
       ✓ その他のヨーロッパ
       ◇ アジア太平洋地域
       ✓ 中国
       ✓ インド
       ✓ 日本
       ✓ オーストラリア
       ✓ 韓国
       ✓ その他のAPAC
       ◇ ラテンアメリカ
       ✓ ブラジル
       ✓ メキシコ
       ◇ 中東・アフリカ
       ✓ サウジアラビア
       ✓ 南アフリカ
       ✓ その他の中東・アフリカ

レポート詳細

目次

Table of Contents

Chapter 1. Executive Summary
1.1. Market Snapshot
1.2. Global & Segmental Market Estimates & Forecasts, 2020-2030 (USD Billion)
1.2.1. Mammalian Cell Fermentation Technology Market, by region, 2020-2030 (USD Billion)
1.2.2. Mammalian Cell Fermentation Technology Market, by Type, 2020-2030 (USD Billion)
1.2.3. Mammalian Cell Fermentation Technology Market, by Application, 2020-2030 (USD Billion)
1.2.4. Mammalian Cell Fermentation Technology Market, by End Use, 2020-2030 (USD Billion)
1.3. Key Trends
1.4. Estimation Methodology
1.5. Research Assumption

Chapter 2. Global Mammalian Cell Fermentation Technology Market Definition and Scope
2.1. Objective of the Study
2.2. Market Definition & Scope
2.2.1. Industry Evolution
2.2.2. Scope of the Study
2.3. Years Considered for the Study
2.4. Currency Conversion Rates

Chapter 3. Global Mammalian Cell Fermentation Technology Market Dynamics
3.1. Mammalian Cell Fermentation Technology Market Impact Analysis (2020-2030)
3.1.1. Market Drivers
3.1.1.1. Growing prevalence of chronic diseases
3.1.1.2. Increasing need for novel and secure therapies
3.1.1.3. Growing demand for biologics and biosimilars
3.1.2. Market Challenges
3.1.2.1. High cost of mammalian cell fermentation technology
3.1.2.2. Stringent government regulations
3.1.3. Market Opportunities
3.1.3.1. Technological advancement
3.1.3.2. Increasing research and development spending

Chapter 4. Global Mammalian Cell Fermentation Technology Market: Industry Analysis
4.1. Porter's 5 Force Model
4.1.1. Bargaining Power of Suppliers
4.1.2. Bargaining Power of Buyers
4.1.3. Threat of New Entrants
4.1.4. Threat of Substitutes
4.1.5. Competitive Rivalry
4.2. Porter's 5 Force Impact Analysis
4.3. PEST Analysis
4.3.1. Political
4.3.2. Economic
4.3.3. Social
4.3.4. Technological
4.3.5. Environmental
4.3.6. Legal
4.4. Top investment opportunity
4.5. Top winning strategies
4.6. COVID-19 Impact Analysis
4.7. Disruptive Trends
4.8. Industry Expert Perspective
4.9. Analyst Recommendation & Conclusion

Chapter 5. Global Mammalian Cell Fermentation Technology Market, by Type
5.1. Market Snapshot
5.2. Global Mammalian Cell Fermentation Technology Market by Type, Performance - Potential Analysis
5.3. Global Mammalian Cell Fermentation Technology Market Estimates & Forecasts by Type 2020-2030 (USD Billion)
5.4. Mammalian Cell Fermentation Technology Market, Sub Segment Analysis
5.4.1. Hamster Ovary (CHO) Cell Fermentation
5.4.2. Human Embryonic Kidney (HEK) Cell Fermentation
5.4.3. Baby Hamster Kidney (BHK) Cell Fermentation
5.4.4. Murine Myeloma Cell Fermentation
5.4.5. Others

Chapter 6. Global Mammalian Cell Fermentation Technology Market, by Application
6.1. Market Snapshot
6.2. Global Mammalian Cell Fermentation Technology Market by Application, Performance - Potential Analysis
6.3. Global Mammalian Cell Fermentation Technology Market Estimates & Forecasts by Application 2020-2030 (USD Billion)
6.4. Mammalian Cell Fermentation Technology Market, Sub Segment Analysis
6.4.1. Monoclonal Antibodies
6.4.2. Recombinant Proteins
6.4.3. Vaccines
6.4.4. Hormones
6.4.5. Enzymes
6.4.6. Others

Chapter 7. Global Mammalian Cell Fermentation Technology Market, by End Use
7.1. Market Snapshot
7.2. Global Mammalian Cell Fermentation Technology Market by End Use, Performance - Potential Analysis
7.3. Global Mammalian Cell Fermentation Technology Market Estimates & Forecasts by End Use 2020-2030 (USD Billion)
7.4. Mammalian Cell Fermentation Technology Market, Sub Segment Analysis
7.4.1. Biopharmaceutical Companies
7.4.2. CMOs & CDMOs
7.4.3. Academic & Research Institutes

Chapter 8. Global Mammalian Cell Fermentation Technology Market, Regional Analysis
8.1. Top Leading Countries
8.2. Top Emerging Countries
8.3. Mammalian Cell Fermentation Technology Market, Regional Market Snapshot
8.4. North America Mammalian Cell Fermentation Technology Market
8.4.1. U.S. Mammalian Cell Fermentation Technology Market
8.4.1.1. Type breakdown estimates & forecasts, 2020-2030
8.4.1.2. Application breakdown estimates & forecasts, 2020-2030
8.4.1.3. End Use breakdown estimates & forecasts, 2020-2030
8.4.2. Canada Mammalian Cell Fermentation Technology Market
8.5. Europe Mammalian Cell Fermentation Technology Market Snapshot
8.5.1. U.K. Mammalian Cell Fermentation Technology Market
8.5.2. Germany Mammalian Cell Fermentation Technology Market
8.5.3. France Mammalian Cell Fermentation Technology Market
8.5.4. Spain Mammalian Cell Fermentation Technology Market
8.5.5. Italy Mammalian Cell Fermentation Technology Market
8.5.6. Rest of Europe Mammalian Cell Fermentation Technology Market
8.6. Asia-Pacific Mammalian Cell Fermentation Technology Market Snapshot
8.6.1. China Mammalian Cell Fermentation Technology Market
8.6.2. India Mammalian Cell Fermentation Technology Market
8.6.3. Japan Mammalian Cell Fermentation Technology Market
8.6.4. Australia Mammalian Cell Fermentation Technology Market
8.6.5. South Korea Mammalian Cell Fermentation Technology Market
8.6.6. Rest of Asia Pacific Mammalian Cell Fermentation Technology Market
8.7. Latin America Mammalian Cell Fermentation Technology Market Snapshot
8.7.1. Brazil Mammalian Cell Fermentation Technology Market
8.7.2. Mexico Mammalian Cell Fermentation Technology Market
8.8. Middle East & Africa Mammalian Cell Fermentation Technology Market
8.8.1. Saudi Arabia Mammalian Cell Fermentation Technology Market
8.8.2. South Africa Mammalian Cell Fermentation Technology Market
8.8.3. Rest of Middle East & Africa Mammalian Cell Fermentation Technology Market

Chapter 9. Competitive Intelligence
9.1. Key Company SWOT Analysis
9.1.1. Company 1
9.1.2. Company 2
9.1.3. Company 3
9.2. Top Market Strategies
9.3. Company Profiles
9.3.1. Thermo Fisher Scientific, Inc.
9.3.1.1. Key Information
9.3.1.2. Overview
9.3.1.3. Financial (Subject to Data Availability)
9.3.1.4. Product Summary
9.3.1.5. Recent Developments
9.3.2. Merck KGaA
9.3.3. Danaher Corporation
9.3.4. Lonza Group
9.3.5. Hoffmann-La Roche Ltd
9.3.6. Sartorius AG
9.3.7. AstraZeneca
9.3.8. Bristol-Myers Squibb
9.3.9. Amgen Inc.
9.3.10. Gilead Sciences Inc.

Chapter 10. Research Process
10.1. Research Process
10.1.1. Data Mining
10.1.2. Analysis
10.1.3. Market Estimation
10.1.4. Validation
10.1.5. Publishing
10.2. Research Attributes
10.3. Research Assumption

LIST OF TABLES
TABLE 1. Global Mammalian Cell Fermentation Technology Market, report scope
TABLE 2. Global Mammalian Cell Fermentation Technology Market estimates & forecasts by Region 2020-2030 (USD Billion)
TABLE 3. Global Mammalian Cell Fermentation Technology Market estimates & forecasts by Type 2020-2030 (USD Billion)
TABLE 4. Global Mammalian Cell Fermentation Technology Market estimates & forecasts by Application 2020-2030 (USD Billion)
TABLE 5. Global Mammalian Cell Fermentation Technology Market estimates & forecasts by End Use 2020-2030 (USD Billion)
TABLE 6. Global Mammalian Cell Fermentation Technology Market by segment, estimates & forecasts, 2020-2030 (USD Billion)
TABLE 7. Global Mammalian Cell Fermentation Technology Market by region, estimates & forecasts, 2020-2030 (USD Billion)
TABLE 8. Global Mammalian Cell Fermentation Technology Market by segment, estimates & forecasts, 2020-2030 (USD Billion)
TABLE 9. Global Mammalian Cell Fermentation Technology Market by region, estimates & forecasts, 2020-2030 (USD Billion)
TABLE 10. Global Mammalian Cell Fermentation Technology Market by segment, estimates & forecasts, 2020-2030 (USD Billion)
TABLE 11. Global Mammalian Cell Fermentation Technology Market by region, estimates & forecasts, 2020-2030 (USD Billion)
TABLE 12. Global Mammalian Cell Fermentation Technology Market by segment, estimates & forecasts, 2020-2030 (USD Billion)
TABLE 13. Global Mammalian Cell Fermentation Technology Market by region, estimates & forecasts, 2020-2030 (USD Billion)
TABLE 14. Global Mammalian Cell Fermentation Technology Market by segment, estimates & forecasts, 2020-2030 (USD Billion)
TABLE 15. Global Mammalian Cell Fermentation Technology Market by region, estimates & forecasts, 2020-2030 (USD Billion)
TABLE 16. U.S. Mammalian Cell Fermentation Technology Market estimates & forecasts, 2020-2030 (USD Billion)
TABLE 17. U.S. Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 18. U.S. Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 19. Canada Mammalian Cell Fermentation Technology Market estimates & forecasts, 2020-2030 (USD Billion)
TABLE 20. Canada Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 21. Canada Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 22. UK Mammalian Cell Fermentation Technology Market estimates & forecasts, 2020-2030 (USD Billion)
TABLE 23. UK Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 24. UK Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 25. Germany Mammalian Cell Fermentation Technology Market estimates & forecasts, 2020-2030 (USD Billion)
TABLE 26. Germany Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 27. Germany Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 28. France Mammalian Cell Fermentation Technology Market estimates & forecasts, 2020-2030 (USD Billion)
TABLE 29. France Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 30. France Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 31. Italy Mammalian Cell Fermentation Technology Market estimates & forecasts, 2020-2030 (USD Billion)
TABLE 32. Italy Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 33. Italy Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 34. Spain Mammalian Cell Fermentation Technology Market estimates & forecasts, 2020-2030 (USD Billion)
TABLE 35. Spain Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 36. Spain Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 37. RoE Mammalian Cell Fermentation Technology Market estimates & forecasts, 2020-2030 (USD Billion)
TABLE 38. RoE Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 39. RoE Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 40. China Mammalian Cell Fermentation Technology Market estimates & forecasts, 2020-2030 (USD Billion)
TABLE 41. China Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 42. China Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 43. India Mammalian Cell Fermentation Technology Market estimates & forecasts, 2020-2030 (USD Billion)
TABLE 44. India Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 45. India Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 46. Japan Mammalian Cell Fermentation Technology Market estimates & forecasts, 2020-2030 (USD Billion)
TABLE 47. Japan Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 48. Japan Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 49. South Korea Mammalian Cell Fermentation Technology Market estimates & forecasts, 2020-2030 (USD Billion)
TABLE 50. South Korea Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 51. South Korea Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 52. Australia Mammalian Cell Fermentation Technology Market estimates & forecasts, 2020-2030 (USD Billion)
TABLE 53. Australia Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 54. Australia Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 55. RoAPAC Mammalian Cell Fermentation Technology Market estimates & forecasts, 2020-2030 (USD Billion)
TABLE 56. RoAPAC Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 57. RoAPAC Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 58. Brazil Mammalian Cell Fermentation Technology Market estimates & forecasts, 2020-2030 (USD Billion)
TABLE 59. Brazil Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 60. Brazil Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 61. Mexico Mammalian Cell Fermentation Technology Market estimates & forecasts, 2020-2030 (USD Billion)
TABLE 62. Mexico Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 63. Mexico Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 64. RoLA Mammalian Cell Fermentation Technology Market estimates & forecasts, 2020-2030 (USD Billion)
TABLE 65. RoLA Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 66. RoLA Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 67. Saudi Arabia Mammalian Cell Fermentation Technology Market estimates & forecasts, 2020-2030 (USD Billion)
TABLE 68. South Africa Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 69. RoMEA Mammalian Cell Fermentation Technology Market estimates & forecasts by segment 2020-2030 (USD Billion)
TABLE 70. List of secondary sources, used in the study of global Mammalian Cell Fermentation Technology Market
TABLE 71. List of primary sources, used in the study of global Mammalian Cell Fermentation Technology Market
TABLE 72. Years considered for the study
TABLE 73. Exchange rates considered
List of tables and figures are dummy in nature, final lists may vary in the final deliverable

LIST OF FIGURES
FIG 1. Global Mammalian Cell Fermentation Technology Market, research methodology
FIG 2. Global Mammalian Cell Fermentation Technology Market, Market estimation techniques
FIG 3. Global Market size estimates & forecast methods
FIG 4. Global Mammalian Cell Fermentation Technology Market, key trends 2022
FIG 5. Global Mammalian Cell Fermentation Technology Market, growth prospects 2023-2030
FIG 6. Global Mammalian Cell Fermentation Technology Market, porters 5 force model
FIG 7. Global Mammalian Cell Fermentation Technology Market, pest analysis
FIG 8. Global Mammalian Cell Fermentation Technology Market, value chain analysis
FIG 9. Global Mammalian Cell Fermentation Technology Market by segment, 2020 & 2030 (USD Billion)
FIG 10. Global Mammalian Cell Fermentation Technology Market by segment, 2020 & 2030 (USD Billion)
FIG 11. Global Mammalian Cell Fermentation Technology Market by segment, 2020 & 2030 (USD Billion)
FIG 12. Global Mammalian Cell Fermentation Technology Market by segment, 2020 & 2030 (USD Billion)
FIG 13. Global Mammalian Cell Fermentation Technology Market by segment, 2020 & 2030 (USD Billion)
FIG 14. Global Mammalian Cell Fermentation Technology Market, regional snapshot 2020 & 2030
FIG 15. North America Mammalian Cell Fermentation Technology Market 2020 & 2030 (USD Billion)
FIG 16. Europe Mammalian Cell Fermentation Technology Market 2020 & 2030 (USD Billion)
FIG 17. Asia pacific Mammalian Cell Fermentation Technology Market 2020 & 2030 (USD Billion)
FIG 18. Latin America Mammalian Cell Fermentation Technology Market 2020 & 2030 (USD Billion)
FIG 19. Middle East & Africa Mammalian Cell Fermentation Technology Market 2020 & 2030 (USD Billion)
List of tables and figures are dummy in nature, final lists may vary in the final deliverable

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