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Chapter-1: SUMMARY

SUMMARY
SUMMARY TABLE GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET BY INDUSTRY, THROUGH 2013 ($ MILLIONS)
SUMMARY FIGURE GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET BY INDUSTRY, 2006-2013 ($ MILLIONS)

Chapter-2: OVERVIEW

SYNTHETIC BIOLOGY TECHNOLOGIES COVERED IN THIS REPORT
TABLE 1 SCOPE OF THIS REPORT
WHAT IS SYNTHETIC BIOLOGY?
DEVELOPMENT STAGE OF SYNTHETIC BIOLOGY
FORCES DRIVING SYNTHETIC BIOLOGY MARKET GROWTH
TABLE 2 SYNTHETIC BIOLOGY GROWTH DRIVING FORCES
GLOBAL MARKET POTENTIAL FOR SYNTHETIC BIOLOGY PRODUCTS
TABLE 3 GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET BY END USER, THROUGH 2013 ($ MILLIONS)
TABLE 4 GLOBAL VALUE OF SYNTHETIC BIOLOGY-ENABLED ENERGY MARKET BY FUEL TYPE, THROUGH 2013 ($ MILLIONS)
LIFE CYCLE STATUS OF SYNTHETIC BIOLOGY TECHNOLOGIES
TABLE 5 SYNTHETIC BIOLOGY PRODUCTS AND TECHNOLOGY LIFE CYCLE STAGE
THE SYNTHETIC BIOLOGY INDUSTRY
TABLE 6 SYNTHETIC BIOLOGY KEY COMPETITORS BY MARKET FOCUS

Chapter-3: SYNTHETIC BIOLOGY TECHNOLOGIES

INTRODUCTION
DEFINITION OF SYNTHETIC BIOLOGY
TABLE 7 SYNTHETIC BIOLOGY DEFINITIONS
HISTORY OF SYNTHETIC BIOLOGY
TABLE 8 SYNTHETIC BIOLOGY HISTORY
PARADIGM SHIFT IN BIOLOGY
TABLE 9 PARADIGM SHIFT OF BIOLOGY
TABLE 10 GENETIC ENGINEERING AND SYNTHETIC BIOLOGY COMPARED
FIGURE 1 SCALE OF SYNTHETIC BIOLOGY
SYNTHETIC BIOLOGY TECHNOLOGY OVERVIEW
TABLE 11 SYNTHETIC BIOLOGY APPLICATIONS BY TECHNOLOGY
ENABLING TECHNOLOGIES
TABLE 12 IMPORTANCE OF ENABLING TECHNOLOGIES
COSTS OF DNA SYNTHESIS AND SEQUENCING
FIGURE 2 DNA SYNTHESIS AND SEQUENCING COSTS, 1990--2008 ($)
FIGURE 3 HUMAN GENOME SEQUENCING COSTS, 1990--2015 ($)
DNA SYNTHESIS TECHNOLOGIES
FIGURE 4 SIMPLIFIED SCHEMATIC OF GENE SYNTHESIS TECHNOLOGY
TABLE 13 COMPARISON OF GENE SYNTHESIS TECHNOLOGIES
PCR-Based Approaches
Solid-Phase Approaches
MICROFLUIDICS TECHNOLOGIES
TABLE 14 IMPORTANCE OF MICROFLUIDICS TECHNOLOGIES IN SYNTHETIC BIOLOGY
DNA Microarrays―Oligos Synthesis
TABLE 15 MICROARRAY TYPES
TABLE 16 DNA MICROARRAY PLATFORM FEATURES
TABLE 17 DNA MICROARRAY PLATFORM COMPARISON FOR MAJOR MANUFACTURERS
FIGURE 5 MICROARRAYS IN GENE SYNTHESIS
DNA SEQUENCING TECHNOLOGIES
FIGURE 6 SEQUENCING THROUGHPUT TREND, 1977--2008
FIGURE 7 DNA SEQUENCING TECHNOLOGIES
BIOINFORMATICS TECHNOLOGIES
TABLE 18 SYNTHETIC BIOLOGY BIOINFORMATICS TECHNOLOGIES
BIOLOGICAL COMPONENTS AND INTEGRATED SYSTEMS TECHNOLOGIES
TABLE 19 NUCLEIC ACIDS, GENES, AND GENOMES
SYNTHETIC GENES
TABLE 20 SYNTHETIC GENES AS MOLECULAR BIOLOGY TOOL
TABLE 21 SYNTHETIC GENES VERSUS PCR CLONING
BIOBRICKS/IGEM PARTS
TABLE 22 BIOBRICKS/IGEM PARTS
FIGURE 8 ROLE OF PROMOTERS AND REPORTERS IN SYNTHETIC BIOLOGY SYSTEMS
MINIMAL GENOMES AND CHASSIS ORGANISMS
TABLE 23 ATTRIBUTES OF A MINIMAL GENOME
CASE STUDY: MINIMAL E.COLI GENOME
Role of Directed Evolution in Designing Biologic Parts
ENABLED TECHNOLOGIES
OVERVIEW
TABLE 24 ENABLED TECHNOLOGIES: EXISTING AND NEAR-TERM APPLICATIONS
Pathway Engineering
FIGURE 9 HOW SYNTHETIC BIOLOGY CREATES ENABLED PRODUCTS
TABLE 25 METABOLIC ENGINEERING FOR ARTEMISINIC ACID
Synthetic Microbial Consortia
TABLE 26 APPLICATIONS FOR SYNTHETIC MICROBIAL CONSORTIA
BIOFUELS TECHNOLOGIES
Biofuels Feedstocks
TABLE 27 ENERGY BALANCE OF SELECTED FIRST-GENERATION BIOFUEL FEEDSTOCKS
Advanced-Generation Biofuels
TABLE 28 FIRST- AND ADVANCED-GENERATION BIOFUELS COMPARED
Cellulosic Biomass
FIGURE 10 APPROXIMATE COMPOSITION OF CELLULOSIC BIOMASS (%)
TABLE 29 SYNTHETIC BIOLOGY STRATEGIES FOR CONVERTING CELLULOSIC BIOMASS INTO ETHANOL
Biofuels Types
TABLE 30 EFFICIENCY OF VARIOUS FUELS
Cellulosic Ethanol
FIGURE 11 CELLULOSIC ETHANOL PRODUCTION SCHEMATIC
TABLE 31 CORN ETHANOL COST TARGETS, 2009 ($/GAL. OF ETHANOL)
FIGURE 12 ESTIMATED 25 MGY CELLULOSIC ETHANOL PLANT COSTS (%)
Biodiesel
TABLE 32 IODINE NUMBER OF VARIOUS OILS
Other Biofuels
Role of Genetic Engineering and Synthetic Biology in Biofuels
TABLE 33 CONTRIBUTION OF SYNTHETIC BIOLOGY TO BIOFUELS

Chapter-4: SYNTHETIC BIOLOGY APPLICATIONS

INTRODUCTION
ENABLING TECHNOLOGIES
TABLE 34 SYNTHETIC BIOLOGY PRODUCTS IMPACTED BY ENABLING TECHNOLOGIES
BIOLOGIC COMPONENTS AND INTEGRATED SYSTEMS APPLICATIONS
TABLE 35 BIOLOGICAL COMPONENTS AND INTEGRATED SYSTEMS NEAR-TERM APPLICATIONS
SYNTHETIC GENE APPLICATIONS
TABLE 36 SYNTHETIC GENES NEAR-TERM APPLICATIONS
BIOBRICKS/IGEM PARTS APPLICATIONS
INTEGRATED SYSTEMS APPLICATIONS
Synthetic Cells and Tissues
ENABLED PRODUCTS APPLICATIONS
TABLE 37 ENABLED PRODUCTS NEAR-TERM APPLICATIONS
APPLICATIONS BY END-USER INDUSTRY
RESEARCH AND DEVELOPMENT APPLICATIONS
TABLE 38 RESEARCH & DEVELOPMENT APPLICATIONS FOR SYNTHETIC BIOLOGY PRODUCTS
PHARMACEUTICALS APPLICATIONS
TABLE 39 DRUG DISCOVERY AND DEVELOPMENT APPLICATIONS FOR SYNTHETIC BIOLOGY PRODUCTS
TABLE 40 PIPELINE OF SYNTHETIC BIOLOGY-ENABLED DRUGS
ENERGY APPLICATIONS
TABLE 41 ETHANOL AND BIODIESEL FEEDSTOCKS AND PRODUCTION PROCESSES
TABLE 42 ETHANOL AND BIODIESEL COMMON BLENDS
TABLE 43 FIRST-GENERATION FUEL ETHANOL GLOBAL PRODUCTION AND GOALS, 2007 (MILLION GALS.)
TABLE 44 FIRST-GENERATION BIODIESEL PRODUCTION AND GOALS, 2007 (MILLION GALS.)
United States
FIGURE 13 RENEWABLE FUELS STANDARDS, UNITED STATES, 2008--2013 (BILLION GALS./ YR)
TABLE 45 DOE FUNDING FOR CELLULOSIC BIOFUELS, 2007--2011 ($ MILLIONS)
Canada
Brazil
CHEMICAL INDUSTRY APPLICATIONS

Chapter-5: SYNTHETIC BIOLOGY INDUSTRY

INDUSTRIAL BIOTECHNOLOGY VALUE CHAIN
FIGURE 14 INDUSTRIAL BIOTECHNOLOGY VALUE CHAIN WITH SYNTHETIC BIOLOGY LEVERAGE POINTS
INDUSTRY STRUCTURAL FORCES
TABLE 46 SYNTHETIC BIOLOGY INDUSTRY STRUCTURAL FORCES
PRODUCTS AND TECHNOLOGY LIFE CYCLE
TABLE 47 SYNTHETIC BIOLOGY PRODUCTS AND TECHNOLOGY LIFE CYCLE STAGE
INDUSTRY COMPETITOR POSITIONING
TABLE 48 SYNTHETIC BIOLOGY KEY COMPETITORS BY MARKET FOCUS
GENE SYNTHESIS INDUSTRY
GENE SYNTHESIS WORKFLOW
TABLE 49 GENE SYNTHESIS WORKFLOW
GENE SYNTHESIS COMPETITOR STRATEGIES
FIGURE 15 SYNTHETIC GENE COMPANY ESTIMATED MARKET SHARES, 2008 (%)
TABLE 50 SYNTHETIC GENE KEY COMPETITOR STRATEGIES
Gene Synthesis Value Chain
Synthetic Gene Market Segments
Automated, Standardized Market Segment
Value-Added Market Segments
TABLE 51 GENE SYNTHESIS MARKET FACTORS OF DIFFERENTIATION
BIOFUELS INDUSTRY
COMPETITIVE DIFFERENTIATION
FEEDSTOCKS
TABLE 52 BIOFUELS: FEEDSTOCKS, PRODUCTION, AND PRODUCTS
FIGURE 16 BIOFUELS FEEDSTOCKS: RELATIVE COSTS AND VOLUMES
Sugars/Starches
Vegetable Oils
Biomass
Algae
TABLE 53 BIODIESEL YIELD OF SELECTED CROPS (GALS./ACRE/YR.)
CO2
CELLULOSIC ETHANOL INDUSTRY
TABLE 54 CELLULOSIC ETHANOL PLANTS (MGY)
BIOFUELS COMPETITOR STRATEGIES
TABLE 55 SYNTHETIC BIOLOGY-BASED BIOFUELS COMPANY STRATEGIES
Agrivida
Amyris
BP
DuPont
Gevo
LS9
Mascoma
OpX Biotechnologies
Sequesco
Solazyme
Synthetic Genomics
Verdezyne
Verenium
ROLE OF BIOFUELS FOUNDERS AND INVESTORS
TABLE 56 ROLE OF INVESTORS AND FOUNDERS IN BIOFUELS COMPANIES
ENZYMES INDUSTRY
TABLE 57 ENZYME COMPANY KEY ALLIANCES
PHARMACEUTICALS INDUSTRY
TABLE 58 PHARMACEUTICALS COMPANY STRATEGIES
INDUSTRY ACQUISITIONS AND STRATEGIC ALLIANCES
TABLE 59 INDUSTRY ACQUISITIONS, 2006--2008
TABLE 60 SYNTHETIC BIOLOGY STRATEGIC ALLIANCES, 2006--2009
BIODEFENSE ISSUES
TABLE 61 FUTURE SYNTHETIC BIOLOGY SECURITY REGULATIONS
SUPPORTING INDUSTRY ORGANIZATIONS
TABLE 62 SYNTHETIC BIOLOGY ENABLING ORGANIZATIONS
FIGURE 17 GROWTH IN IGEM (NUMBER)

Chapter-6: SYNTHETIC BIOLOGY MARKETS

GROWTH DRIVING FORCES
TABLE 63 SYNTHETIC BIOLOGY GROWTH DRIVING FORCES
FIGURE 18 NIH BUDGET OUTLAYS, 2000--2009 ($ BILLIONS)
FIGURE 19 SYNTHETIC BIOLOGY RESEARCH PUBLICATIONS, 2000--2008 (NUMBER)
MARKET FORECASTS
FIGURE 20 MARKET FORECAST SCENARIO TABLE
SYNTHETIC BIOLOGY MARKETS BY INDUSTRY
Summary
TABLE 64 GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET BY END USER, THROUGH 2013 ($ MILLIONS)
R&D Market
TABLE 65 GLOBAL VALUE OF R&D MARKET BY APPLICATION, THROUGH 2013 ($ MILLIONS)
Biotechnology and Pharmaceuticals Market
TABLE 66 GLOBAL VALUE OF BIOTECHNOLOGY AND PHARMACEUTICALS MARKET BY PRODUCT TYPE, THROUGH 2013 ($ MILLIONS)
Chemicals Market
TABLE 67 GLOBAL VALUE OF CHEMICALS MARKET BY PRODUCT TYPE, THROUGH 2013 ($ MILLIONS)
Energy Market
TABLE 68 GLOBAL VALUE OF ENERGY MARKET BY PRODUCT TYPE, THROUGH 2013 ($ MILLIONS)
FIGURE 21 S-CURVE FOR SECOND-GENERATION BIOFUELS
TABLE 69 WORLD BIODIESEL PRODUCTION AND CAPACITY TRENDS, 2002--2008 (MILLIONS TONS/YR)
TABLE 70 GLOBAL BIOFUELS SUPPLY BY PRODUCT CLASS, THROUGH 2013 (KBOED)
FIGURE 22 GLOBAL BIOFUELS MARKET, 2013 (GALS./YR.)
FIGURE 23 GLOBAL CELLULOSIC SECOND-GENERATION BIOFUELS MARKET, 2013 (GALS./YR)
FIGURE 24 UNITED STATES BIOFUELS MARKET GOALS, 2022 (%)
SYNTHETIC BIOLOGY MARKETS BY PRODUCT TYPE
Summary
TABLE 71 GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET BY PRODUCT TYPE, THROUGH 2013 ($ MILLIONS)
Enabling Products Market
TABLE 72 GLOBAL VALUE OF SYNTHETIC BIOLOGY-ENABLING PRODUCTS MARKET, THROUGH 2013 ($ MILLIONS)
Biological Parts Market
TABLE 73 GLOBAL VALUE OF DNA SYNTHESIS MARKET BY TYPE, THROUGH 2013 ($ MILLIONS)
TABLE 74 GLOBAL VALUE OF BIOLOGIC PARTS MARKET BY TYPE, THROUGH 2013 ($ MILLIONS)
Standardized Market Segment
Value-Added Market Segments
TABLE 75 GLOBAL VALUE OF BIOLOGIC PARTS MARKET BY END USER INDUSTRY, THROUGH 2013 ($ MILLIONS)
TABLE 76 GLOBAL VALUE OF BIOLOGIC PARTS BY SUPPLIER TYPE, THROUGH 2013 ($ MILLIONS)
TABLE 77 HOMEBREW VERSUS COMMERCIAL COST COMPARISON FOR SYNTHESIZING A TYPICAL 714 BP GFP GENE ($)
Integrated Systems Market
TABLE 78 GLOBAL VALUE OF SYNTHETIC BIOLOGY INTEGRATED SYSTEMS MARKET BY TYPE, THROUGH 2013 ($ MILLIONS)
Enabled Products Market
TABLE 79 GLOBAL VALUE OF SYNTHETIC BIOLOGY-ENABLED PRODUCTS MARKET BY INDUSTRY, THROUGH 2013 ($ MILLIONS)
TABLE 80 GLOBAL VALUE OF ENABLED R&D MARKET BY PRODUCT TYPE, THROUGH 2013 ($ MILLIONS)
TABLE 81 GLOBAL VALUE OF ENABLED PHARMACEUTICALS MARKET BY PRODUCT TYPE, THROUGH 2013 ($ MILLIONS)
TABLE 82 GLOBAL VALUE OF ENABLED CHEMICALS MARKET BY PRODUCT TYPE, THROUGH 2013 ($ MILLIONS)
TABLE 83 GLOBAL VALUE OF SYNTHETIC BIOLOGY-ENABLED ENERGY MARKET BY FUEL TYPE, THROUGH 2013 ($ MILLIONS)
SYNTHETIC BIOLOGY MARKET BY GEOGRAPHIC REGION
Summary
TABLE 84 GLOBAL VALUE OF SYNTHETIC BIOLOGY MARKET BY GEOGRAPHIC REGION, THROUGH 2013 ($ MILLIONS)
Importance of Geography to Fuels Markets

Chapter-7: PATENT STATUS

INTRODUCTION
FOUNDATIONAL PATENTS
TABLE 85 SYNTHETIC BIOLOGY FOUNDATIONAL PATENTS
SYNTHETIC BIOLOGY INDUSTRY PATENT ANALYSIS
FIGURE 25 NUMBER OF PATENTS BY COMPANY
TABLE 86 PATENT DESCRIPTION BY COMPANY
FIGURE 26 SYNTHETIC BIOLOGY PATENTS BY COMPANY AND SUBCLASS (NUMBER OF PATENTS)
LITIGATION STATUS
TABLE 87 IP LITIGATION STATUS
IP STRATEGY OF SELECTED SYNTHETIC BIOLOGY COMPANIES
METABOLIX
DUPONT
GENEART
FEBIT

Chapter-8: COMPANY PROFILES

AGRIVIDA
AMYRIS BIOTECHNOLOGIES, INC.
TABLE 88 AMYRIS BIODIESEL ADVANTAGES
ATG BIOSYNTHETICS GMBH
BASF AG
BIO BASIC, INC.
BIOCAT GMBH
BIONEER CORP.
BIONEXUS, INC.
BIO S&T, INC.
BIOTICA TECHNOLOGY, LTD.
TABLE 89 STRUCTURE-FUNCTION APPROACH FOR RAPAMYCIN
TABLE 90 BIOTICA PROJECTS PIPELINE
BLUE HERON BIOTECHNOLOGIES
BRISTOL-MYERS SQUIBB
BRITISH PETROLEUM
CELLICON BIOTECHNOLOGIES, INC.
CODEXIS, INC.
CODON DEVICES, INC.
DANISCO A/S
DNA 2.0
TABLE 91 DNA2.0 STRATEGIC ALLIANCES
DRATHS CORP.
DUPONT
DYADIC INTERNATIONAL, INC.
ENTELECHON GMBH
EPOCH BIOLABS, INC.
ERAGEN BIOSCIENCES, INC.
EUROFINS MEDIGENOMIX GMBH
EUROFINS MWG OPERON
FEBIT SYNBIO GMBH
GENEART AG
TABLE 92 GENEART MAJOR STRATEGIC ALLIANCES
GENEMED SYNTHESIS, INC.
GENSCRIPT CORP.
GENEWORKS PTY, LTD.
GEVO, INC.
TABLE 93 GEVO ISOBUTANOL PRODUCTION FORECAST (GALS./YR.)
HELICOS BIOSCIENCES CORP.
INTEGRATED DNA TECHNOLOGIES
ILLUMINA, INC.
INSTITUTE FOR ONEWORLD HEALTH
IOGEN CORP.
JOULE BIOTECHNOLOGIES, INC.
KHOSLA VENTURES
TABLE 94 KHOSLA VENTURES BIOFUELS INVESTMENT PORTFOLIO
LC SCIENCES
LIFE TECHNOLOGIES
LS9, INC.
MASCOMA
TABLE 95 MASCOMA INTELLECTUAL PROPERTY STATUS
MAXYGEN
MERCK & CO.
METABOLIX, INC.
TABLE 96 METABOLOMIX BUSINESS STRATEGY
METRIGEN, INC.
NOVOZYMES A/S
OMEGA BIO-TEK, INC.
OPX BIOTECHNOLOGIES, INC.
PACIFIC BIOSCIENCES
PFIZER
PROTOLIFE SRL
QTEROS
ROCHE LIFE SCIENCES
ROYAL DSM N.V.
SANGAMO BIOSCIENCES, INC.
SANOFI AVENTIS
SCARAB GENOMICS, LLC
SEQUESCO
SLONING BIOTECHNOLOGY, GMBH
SOLAZYME, INC.
TABLE 97 SOLAZYME STRATEGIC ALLIANCES
SYNTHETIC GENOMICS
TABLE 98 SYNTHETIC GENOMICS STRATEGIC ALLIANCES
VERDEZYNE
TABLE 99 VERDEZYNE STRATEGIC COLLABORATIONS
VERENIUM CORP.