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Chapter-1: INTRODUCTION

STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
INTENDED AUDIENCE
SCOPE OF REPORT
METHODOLOGY AND INFORMATION SOURCES
ANALYST CREDENTIALS
RELATED BCC REPORTS
BCC ONLINE SERVICES
DISCLAIMER

Chapter-2: EXECUTIVE SUMMARY

EXECUTIVE SUMMARY
SUMMARY TABLE GLOBAL PRESCRIPTION AND OTC GASTROINTESTINAL DISORDER TREATMENT MARKET, THROUGH 2014 ($ MILLIONS)
SUMMARY FIGURE GLOBAL PRESCRIPTION AND OTC GASTROINTESTINAL DISORDER TREATMENT MARKET, 2007-2014 ($ MILLIONS)

Chapter-3: INDUSTRY OVERVIEW

STRUCTURE AND FUNCTION OF THE GASTROINTESTINAL SYSTEM
INGESTION AND PROPULSION OF FOOD
Mouth
Pharynx
Esophagus
DIGESTION AND ABSORPTION
Mouth
Stomach
Small Intestines
Physiology of Digestion
ELIMINATION
Large Intestine
LIVER, BILIARY TRACT AND PANCREAS
LIVER
BILIARY TRACT
Bilirubin Metabolism
PANCREAS
GASTROINTESTINAL TRACT DISORDERS
DYSPHAGIA
ESOPHAGEAL AND ABDOMINAL PAIN
VOMITING
INTESTINAL GAS
CONSTIPATION
DIARRHEA
TABLE 1 CAUSES OF DIARRHEA
GASTROINTESTINAL TRACT WALL DISORDERS
GASTRITIS
TABLE 2 COMMON CAUSES OF GASTRITIS
GASTROENTERITIS
PEPTIC ULCER DISEASE
GASTRIC ULCERS
DUODENAL ULCERS
INFLAMMATORY BOWEL DISEASE
ULCERATIVE COLITIS
CROHN'S DISEASE
ENTEROCOLITIS
DIVERTICULAR DISEASE
GASTROINTESTINAL TRACT MOTILITY DISORDERS
IRRITABLE BOWEL SYNDROME
INTESTINAL OBSTRUCTION
GASTROINTESTINAL MALABSORPTION DISORDERS
CELIAC DISEASE
TROPICAL SPRUE
CANCERS OF THE GASTROINTESTINAL TRACT
ESOPHAGEAL CANCER
GASTRIC CANCER
LIVER CANCER
PANCREATIC CANCER
SMALL INTESTINAL CANCER
COLONIC POLYPS AND COLON CANCER
U.S. DEMOGRAPHICS
TABLE 3 U.S. ESTIMATED INCIDENCE/PREVALENCE/MORTALITY OF SELECTED GASTROINTESTINAL CONDITIONS
TABLE 4 U.S. POPULATION BY SELECTED AGE GROUPS, 2009 AND 2014 (THOUSANDS)
FIGURE 1 U.S. POPULATION BY SELECTED AGE GROUPS, 2009 AND 2014 (THOUSANDS)
FIGURE 2 U.S. POPULATION SELECTED AGE GROUPS BY PERCENT OF TOTAL POPULATION, 2009 AND 2014 (%)
PILL-SIZED VIDEO CAMERA
PILLCAM ESO
SMARTPILL
RADIO FREQUENCY IDENTIFICATION TECHNOLOGY
IPHONE APPLICATION
ENTERIC NERVOUS SYSTEM
INSURANCE COVERAGE
MONOCLONAL ANTIBODIES
WYETH IN SUIT WITH STATES
GENERIC INFLUENCE
BRANDED VS OTC PROTON PUMP INHIBITORS
MAIL ORDER TRENDS

Chapter-4: PRESCRIPTION PRODUCT SEGMENTS BY TYPE

ANTIDIARRHEALS
SYSTEMICALLY ACTING ANTIDIARRHEALS
OPIUM PRODUCTS
TABLE 5 MARKETED ANTIDIARRHEAL PRODUCTS
MARKET SIZE AND GROWTH
TABLE 6 GLOBAL PRESCRIPTION ANTIDIARRHEAL MARKET, BY REGION, THROUGH 2014 ($ MILLIONS)
FIGURE 3 GLOBAL PRESCRIPTION ANTIDIARRHEAL MARKET, BY REGION, THROUGH 2014 ($ MILLIONS)
COMPETITIVE STRUCTURE AND MARKET SHARE
TABLE 7 GLOBAL PRESCRIPTION ANTIDIARRHEAL REVENUES AND MARKET SHARE LEVELS, BY MANUFACTURER, 2009 ($ MILLIONS/%)
FIGURE 4 GLOBAL PRESCRIPTION ANTIDIARRHEAL REVENUES, 2009 ($ MILLIONS)
ANTIEMETICS
LOCALLY ACTING ANTIEMETICS
CENTRALLY ACTING ANTIEMETICS
ANTIDOPAMINERGICS
ANTICHOLINERGICS
MISCELLANEOUS ANTIEMETICS
TABLE 8 MARKETED ANTIEMETIC PRODUCTS
MARKET SIZE AND GROWTH
TABLE 9 GLOBAL PRESCRIPTION ANTIEMETIC MARKET BY REGION, THROUGH 2014 ($ MILLIONS)
FIGURE 5 GLOBAL PRESCRIPTION ANTIEMETIC MARKET BY REGION, 2007-2014 ($ MILLIONS)
COMPETITIVE STRUCTURE AND MARKET SHARE
TABLE 10 GLOBAL PRESCRIPTION ANTIEMETIC REVENUES AND MARKET SHARE BY MANUFACTURER, 2009 ($ MILLIONS/%)
FIGURE 6 GLOBAL PRESCRIPTION ANTIEMETICS REVENUES BY MANUFACTURER, 2009 ($ MILLIONS)
GASTROINTESTINAL CANCER TREATMENTS
TABLE 11 MARKETED GASTROINTESTINAL CANCER PRODUCTS
MARKET SIZE AND GROWTH
TABLE 12 GLOBAL PRESCRIPTION GASTROINTESTINAL CANCER DRUG MARKET BY REGION, THROUGH 2014 ($ MILLIONS)
FIGURE 7 GLOBAL PRESCRIPTION GASTROINTESTINAL CANCER DRUG MARKET BY REGION, 2007-2014 ($ MILLIONS)
COMPETITIVE STRUCTURE AND MARKET SHARE
TABLE 13 GLOBAL PRESCRIPTION GASTROINTESTINAL CANCER DRUG REVENUES AND MARKET SHARE, 2009 ($ MILLIONS/%)
FIGURE 8 GLOBAL PRESCRIPTION GASTROINTESTINAL CANCER DRUG REVENUES, 2009 ($ MILLIONS)
H2 INHIBITORS
TABLE 14 MARKETED H2 INHIBITORS PRODUCTS
MARKET SIZE AND GROWTH
TABLE 15 GLOBAL PRESCRIPTION H2 INHIBITOR MARKET BY REGION, THROUGH 2014 ($ MILLIONS)
FIGURE 9 GLOBAL PRESCRIPTION H2 INHIBITOR MARKET BY REGION, 2007-2014 ($ MILLIONS)
COMPETITIVE STRUCTURE AND MARKET SHARE
TABLE 16 GLOBAL PRESCRIPTION H2 INHIBITOR REVENUES AND MARKET SHARE, 2009 ($ MILLIONS/%)
FIGURE 10 GLOBAL PRESCRIPTION H2 INHIBITOR REVENUES, 2009 ($ MILLIONS)
LAXATIVES
TABLE 17 MARKETED LAXATIVE PRODUCTS
MARKET SIZE AND GROWTH
TABLE 18 GLOBAL PRESCRIPTION LAXATIVE MARKET BY REGION, THROUGH 2014 ($ MILLIONS)
FIGURE 11 GLOBAL PRESCRIPTION LAXATIVE MARKET BY REGION, 2007-2014 ($ MILLIONS)
COMPETITIVE STRUCTURE AND MARKET SHARE
TABLE 19 GLOBAL PRESCRIPTION LAXATIVE REVENUES AND MARKET SHARE, 2009 ($ MILLIONS/%)
FIGURE 12 GLOBAL PRESCRIPTION LAXATIVE REVENUES, 2009 ($ MILLIONS)
PROTON PUMP INHIBITORS
TABLE 20 MARKETED PROTON PUMP INHIBITOR PRODUCTS
MARKET SIZE AND GROWTH
TABLE 21 GLOBAL PRESCRIPTION PROTON PUMP INHIBITOR MARKET BY REGION, THROUGH 2014 ($ MILLIONS)
FIGURE 13 GLOBAL PRESCRIPTION PROTON PUMP INHIBITOR MARKET BY REGION, 2007-2014 ($ MILLIONS)
COMPETITIVE STRUCTURE AND MARKET SHARE
TABLE 22 GLOBAL PRESCRIPTION PROTON PUMP INHIBITOR REVENUES AND MARKET SHARE BY MANUFACTURER, 2009 ($ MILLIONS/%)
FIGURE 14 GLOBAL PRESCRIPTION PROTON PUMP INHIBITOR REVENUES BY MANUFACTURER, 2009 ($ MILLIONS)
BOWEL ANTI-INFLAMMATORY
TABLE 23 MARKETED BOWEL ANTI-INFLAMMATORY PRODUCTS
MARKET SIZE AND GROWTH
TABLE 24 GLOBAL PRESCRIPTION BOWEL INFLAMMATORY AGENT MARKET BY REGION, THROUGH 2014 ($ MILLIONS)
FIGURE 15 GLOBAL PRESCRIPTION BOWEL INFLAMMATORY AGENT MARKET BY REGION, 2007-2014 ($ MILLIONS)
COMPETITIVE STRUCTURE AND MARKET SHARE
TABLE 25 GLOBAL PRESCRIPTION BOWEL INFLAMMATORY AGENT REVENUES AND MARKET SHARE, 2009 ($ MILLIONS/%)
FIGURE 16 GLOBAL PRESCRIPTION BOWEL INFLAMMATORY AGENT REVENUES BY MANUFACTURER, 2009 ($ MILLIONS)
OTHER GASTROINTESTINAL PRODUCTS
ANTISPASMODICS
TABLE 26 MARKETED ANTISPASMODIC PRODUCTS
DIGESTANTS
GASTRIC ACIDIFIERS
PANCREATIC ENZYMES
TABLE 27 MARKETED DIGESTANT PRODUCTS
EVACUANTS
TABLE 28 MARKETED EVACUANTS PRODUCTS
MUCOSAL PROTECTANTS
TABLE 29 MARKETED MUCOSAL PROTECTANT PRODUCTS
PROSTAGLANDINS
TABLE 30 MARKETED PROSTAGLANDIN PRODUCTS
STIMULANTS
TABLE 31 MARKETED STIMULANT PRODUCTS
MARKET SIZE AND GROWTH
TABLE 32 GLOBAL PRESCRIPTION OTHER GASTROINTESTINAL DRUG MARKET BY REGION, THROUGH 2014 ($ MILLIONS)
FIGURE 17 GLOBAL PRESCRIPTION OTHER GASTROINTESTINAL DRUG MARKET BY REGION, 2007-2014 ($ MILLIONS)
COMPETITIVE STRUCTURE
TOTAL GLOBAL PRESCRIPTION GASTROINTESTINAL MARKET SIZE AND GROWTH
TABLE 33 GLOBAL PRESCRIPTION GASTROINTESTINAL DISORDER TREATMENT REVENUES BY CATEGORY, THROUGH 2014 ($ MILLIONS)
FIGURE 18 GLOBAL PRESCRIPTION GASTROINTESTINAL DISORDER TREATMENT REVENUES BY CATEGORY, 2007-2014 ($ MILLIONS)
TOTAL U.S. PRESCRIPTION GASTROINTESTINAL COMPETITIVE ANALYSIS
TABLE 34 MANUFACTURERS MARKET SHARE OF PRESCRIPTION GASTROINTESTINAL DISORDER TREATMENT REVENUES, (ESTIMATED 2009)
FIGURE 19 MANUFACTURERS MARKET SHARE OF PRESCRIPTION GASTROINTESTINAL DISORDER TREATMENT REVENUES, 2009 ESTIMATED (%)

Chapter-5: OTC PRODUCT SEGMENTS BY TYPE

ANTACIDS
SYSTEMIC ANTACIDS
Sodium Bicarbonate
NONSYSTEMIC ANTACIDS
Calcium Carbonate
Aluminum Products
Magnesium Products
Combination Products
TABLE 35 MARKETED OTC ANTACID PRODUCTS
MARKET SIZE AND GROWTH
TABLE 36 GLOBAL OTC ANTACID MARKET BY REGION, THROUGH 2014 ($ MILLIONS)
FIGURE 20 GLOBAL OTC ANTACID MARKET BY REGION, 2007-2014 ($ MILLIONS)
COMPETITIVE STRUCTURE AND MARKET SHARE
TABLE 37 GLOBAL OTC ANTACID REVENUES AND MARKET SHARE BY MANUFACTURER, 2009 ($ MILLIONS/%)
FIGURE 21 GLOBAL OTC ANTACID MARKET SHARE BY MANUFACTURER, 2009 (%)
LOCALLY ACTING ANTIDIARRHEALS
ADSORBENTS
INTESTINAL FLORA MODIFIERS
TABLE 38 MARKETED OTC ANTIDIARRHEAL PRODUCTS
MARKET SIZE AND GROWTH
TABLE 39 GLOBAL OTC ANTIDIARRHEALS MARKET BY REGION, THROUGH 2014 ($ MILLIONS)
FIGURE 22 GLOBAL OTC ANTIDIARRHEALS MARKET BY REGION, 2007-2014 ($ MILLIONS)
COMPETITIVE STRUCTURE AND MARKET SHARE
TABLE 40 GLOBAL OTC ANTIDIARRHEALS REVENUES BY MANUFACTURER, 2009 ($ MILLIONS/%)
FIGURE 23 GLOBAL OTC ANTIDIARRHEALS MARKET SHARE BY MANUFACTURER, 2009 (%)
H2 INHIBITORS
TABLE 41 MARKETED OTC H2 INHIBITORS PRODUCTS
MARKET SIZE AND GROWTH
TABLE 42 GLOBAL OTC H2 INHIBITOR MARKET BY REGION, THROUGH 2014 ($ MILLIONS)
FIGURE 24 GLOBAL OTC H2 INHIBITOR MARKET BY REGION, 2007-2014 ($ MILLIONS)
COMPETITIVE STRUCTURE AND MARKET SHARE
TABLE 43 GLOBAL OTC H2 INHIBITOR REVENUES AND MARKET SHARE BY MANUFACTURER, 2009 ($ MILLIONS/%)
FIGURE 25 GLOBAL OTC H2 INHIBITOR MARKET SHARE BY MANUFACTURER, 2009 (%)
PROTON PUMP INHIBITORS
OMEPRAZOLE (PRILOSEC, PROCTER & GAMBLE)
TABLE 44 MARKETED OTC PROTON PUMP INHIBITOR PRODUCTS
MARKET SIZE AND GROWTH
TABLE 45 GLOBAL OTC PROTON PUMP INHIBITOR MARKET BY REGION, THROUGH 2014 ($ MILLIONS)
FIGURE 26 GLOBAL OTC PROTON PUMP INHIBITOR MARKET BY REGION, 2007-2014 ($ MILLIONS)
COMPETITIVE STRUCTURE AND MARKET SHARE
TABLE 46 GLOBAL OTC PROTON PUMP INHIBITOR REVENUES AND MARKET SHARE BY MANUFACTURER, 2009 ($ MILLIONS/%)
FIGURE 27 GLOBAL OTC PROTON PUMP INHIBITOR MARKET SHARE BY MANUFACTURER, 2009 (%)
LAXATIVES
TABLE 47 MARKETED OTC LAXATIVE PRODUCTS
MARKET SIZE AND GROWTH
TABLE 48 GLOBAL OTC LAXATIVES MARKET BY REGION, THROUGH 2014 ($ MILLIONS)
FIGURE 28 GLOBAL OTC LAXATIVE MARKET BY REGION, 2007-2014 ($ MILLIONS)
COMPETITIVE STRUCTURE AND MARKET SHARE
TABLE 49 GLOBAL OTC LAXATIVE REVENUES AND MARKET SHARE BY MANUFACTURER, 2009 ($ MILLIONS/%)
FIGURE 29 GLOBAL OTC LAXATIVE MARKET SHARE BY MANUFACTURER, 2009 (%)
TOTAL OTC GASTROINTESTINAL DRUG MARKET SIZE AND GROWTH
TABLE 50 GLOBAL OTC GASTROINTESTINAL DISORDER TREATMENT MARKET BY PRODUCT CATEGORY, THROUGH 2014 ($ MILLIONS)
FIGURE 30 GLOBAL OTC GASTROINTESTINAL DISORDER TREATMENT MARKET BY PRODUCT CATEGORY, 2007-2014 ($ MILLIONS)
TOTAL OTC GASTROINTESTINAL DRUG COMPETITIVE ANALYSIS
TABLE 51 TOTAL MANUFACTURERS' REVENUES AND MARKET SHARE OF OTC GASTROINTESTINAL DISORDER TREATMENTS, ESTIMATED 2009 ($ MILLIONS/%)
FIGURE 31 TOTAL MANUFACTURERS' MARKET SHARE OF OTC GASTROINTESTINAL DISORDER TREATMENTS, ESTIMATED 2009 (%)
RESEARCH AND DEVELOPMENT
METOSOLV ODT
NEXIUM LOW-DOSE ASPIRIN COMBINATION
REZONIC
SANVAR
TAK-390MR (KAPIDEX)
ZENPEP
AB-1001
ALICAFORSEN
APF 530
CROFELEMER
HUMIRA
LINACLOTIDE
METHYLNALTREXONE (MNTX) (RELSTAR)
MLN 0002 (VEDOLIZUMAB)
ORBEC
PROCHYMAL
RENZAPRIDE
REMICADE
REZULAR
RIFAXIMAN (XIFAXAN)
SUTENT
ALICAFORSEN ENEMA
DEXTOFISOPAM
EKB-569
GTI-2040
PUMOSETRAG
RDP-58
SORAPRAZAN
TALNETANT
BL-1030
BL-1050
TABLE 52 GASTROINTESTINAL DISORDER TREATMENTS IN DEVELOPMENT
TOTAL MARKET ANALYSIS
TABLE 53 GLOBAL PRESCRIPTION AND OTC GASTROINTESTINAL DISORDER MARKET BY CATEGORY, THROUGH 2014 ($ MILLIONS)
FIGURE 32 GLOBAL PRESCRIPTION AND OTC GASTROINTESTINAL DISORDER TREATMENT MARKET BY CATEGORY, 2007-2014 ($ MILLIONS)

Chapter-6: INDUSTRY PARTICIPANTS BY PRODUCT TYPE

TABLE 54 GASTROINTESTINAL DISORDER TREATMENT MANUFACTURERS' REVENUES AND MARKET SHARE BY TYPE, 2009 ($ MILLIONS/%)
FIGURE 33 GASTROINTESTINAL DISORDER TREATMENT MANUFACTURERS' MARKET SHARE BY TYPE, 2009 (%)
COMPANY PROFILES
ASTRAZENECA
History
AXCAN PHARMA, INC.
History
CENTOCOR, INC.
History
EISAI, INC.
History
GENENTECH, INC.
History
GLAXOSMITHKLINE
History
JOHNSON & JOHNSON
History
MCNEIL CONSUMER HEALTHCARE
History
MERCK & CO., INC.
History
NOVARTIS INTERNATIONAL AG
History
PFIZER, INC.
History
PROCTER & GAMBLE CO.
History
ROCHE
History
SANOFI-AVENTIS
History
SALIX PHARMACEUTICALS, LTD.
History
SOLVAY PHARMACEUTICALS
History
TAKEDA PHARMACEUTICALS NORTH AMERICA
History
WYETH
History

Chapter-7: CONTACT INFORMATION FOR GASTROINTESTINAL MARKET PARTICIPANTS

3M CORP.
ABBOTT LABORATORIES
ABEILLE PHARMA, INC.
ACAMBIS, PLC
ACE BIOSCIENCES A/S
AGI THERAPEUTICS, INC.
ALCHEMIA, LTD.
ALIZYME, PLC
ALLERGAN, INC.
ALLSCRIPTS HEALTHCARE SOLUTIONS, INC.
ALTANA PHARMA AG
ALVINE PHARMACEUTICALS, INC.
AMARIN CORP.
AMGEN, INC.
ANTIGENICS, INC.
APOTHECON B.V.
AP PHARMA, INC.
ARCO PHARMACEUTICALS
ASPHELIA PHARMACEUTICALS, INC.
ARYX THERAPEUTICS, INC
ASTELLAS PHARMA, INC.
ASTRAZENECA, PLC
AXCAN PHARMA, INC.
BERTEK (MYLAN LABORATORIES INC.)
BIOBALANCE, INC.
BIOGEN IDEC, INC.
BIOLINERX, LTD.
BRAINTREE LABORATORIES, INC.
BRISTOL-MYERS SQUIBB CO.
CELLDEX THERAPEUTICS, INC.
CENTOCOR ORTHO BIOTECH, INC.
CEPHALON, INC.
CERIMON PHARMA, INC.
CHEMOCENTRYX, INC.
CLAVIS PHARMA ASA
COSMO PHARMACEUTICALS SPA
CYTOKINE PHARMASCIENCES, INC.
DEBIOPHARM S.A.
DOR BIOPHARMA, INC.
EISAI CO., LTD.
ELAN CORPORATION, PLC
EMD SERONO, INC.
ENZO
EURAND PHARMACEUTICALS, INC.
EVOKE PHARMA
FRESENIUS KABI AG
GENENTECH, INC.
GENZYME GENERAL
GLAXOSMITHKLINE, PLC
GLAXOSMITHKLINE CONSUMER HEALTHCARE
GLENMARK PHARMACEUTICALS, LTD.
H3 PHARMA, INC.
HELSINN HEALTHCARE
HOFFMAN-LAROCHE, LTD. (ROCHE)
HYPERION THERAPEUTICS, INC.
IMMUCELL CORP.
ISIS PHARMACEUTICALS. INC.
JANSSEN PHARMACEUTICA PRODUCTS, LP (JOHNSON & JOHNSON)
JOHNSON & JOHNSON
LORUS THERAPEUTICS, INC.
MCNEIL CONSUMER & SPECIALTY PHARMACEUTICALS
MEDISCA, INC.
MERCK & CO., INC.
MONARCH LABS
NABI BIOPHARMACEUTICALS
NOVARTIS CORP.
NPS PHARMACEUTICALS, INC.
OTSUKA AMERICA PHARMACEUTICAL, INC.
PFIZER, INC.
THE PROCTER & GAMBLE CO.
PRODIGENE, INC.
PROGENICS PHARMACEUTICALS, INC.
RAVEN BIOTECHNOLOGIES, INC.
RELIANT PHARMACEUTICALS, INC.
ROXANE LABORATORIES, INC.
SALIX PHARMACEUTICALS, LTD.
SANOFI-AVENTIS
SANTARUS, INC.
SCHERING AG
SCHWARZ PHARMA AG
SERONO S.A.
SHIRE PHARMACEUTICALS GROUP, PLC
SOLVAY S.A.
SUCAMPO PHARMACEUTICALS, INC.
SWISS AGENCY FOR THERAPEUTIC PRODUCTS (SWISSMEDIC)
TAKEDA PHARMACEUTICAL NORTH AMERICA
TARGACEPT, INC.
THERAVANCE, INC.
UCB PHARMA, INC.
UNIMED PHARMACEUTICALS, INC.
PHARMOS PHARMACEUTICALS, INC.
WATSON PHARMACEUTICALS, INC.
WYETH (WHITEHALL-ROBINS HEALTHCARE, INC.)