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Chapter- 1: INTRODUCTION

STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
INTENDED AUDIENCE
SCOPE OF REPORT
METHODOLOGY
INFORMATION SOURCES
ANALYST CREDENTIALS
RELATED BCC REPORTS
BCC ONLINE SERVICES
DISCLAIMER

Chapter-2: SUMMARY

SUMMARY TABLE GLOBAL VALUE OF BIOCHIP PRODUCTS BY TYPE, THROUGH 2014 ($ MILLIONS)
SUMMARY FIGURE GLOBAL VALUE OF BIOCHIP PRODUCTS BY TYPE, 2007-2014 ($ MILLIONS)

Chapter-3: OVERVIEW

INTRODUCTION
TABLE 1 BIOLOGY DOWNSIZING REVOLUTION
FIGURE 1 EVOLUTION OF BIOCHIPS
BIOCHIP TYPES
FIGURE 2 CLASSIFICATION OF BIOCHIPS
TABLE 2 COMPARISON OF THE TWO MAJOR BIOCHIP TYPES
TABLE 3 BIOCHIP NOMENCLATURE
BIOCHIP TECHNOLOGIES COVERED IN THIS REPORT
TABLE 4 SCOPE OF THIS REPORT
WHAT IS NEW IN THIS REPORT
MARKET POTENTIAL OF BIOCHIPS
TABLE 5 GLOBAL VALUE OF BIOCHIP PRODUCTS BY TYPE, THROUGH 2014 ($ MILLIONS)
TABLE 6 GLOBAL VALUE OF BIOCHIP MARKET BY END USE, THROUGH 2014 ($ MILLIONS)
DRIVING FORCES FOR GROWTH IN BIOCHIPS MARKETS
TABLE 7 PRIMARY FORCES DRIVING OVERALL BIOCHIPS GROWTH
BIOCHIPS: A CONVERGENCE OF DIVERSE TECHNOLOGIES
TABLE 8 MULTIDISCIPLINARY FIELD OF BIOCHIPS
LIFE CYCLE STATUS OF BIOCHIP PRODUCTS
TABLE 9 LIFE CYCLE STATUS OF BIOCHIP TYPES
COMMERCIAL STATUS OF BIOCHIPS
MICROARRAYS
LOAC
THE BIOCHIP INDUSTRY
TABLE 10 BIOCHIP INDUSTRY KEY COMPETITORS

Chapter-4: MICROARRAY TECHNOLOGIES

INTRODUCTION
THE NANOSCALE WORLD
TABLE 11 THE NANOSCALE WORLD
TABLE 12 MICROARRAY TYPES
TABLE 13 COMPARISON OF DNA AND PROTEIN MICROARRAY TECHNOLOGIES
DNA MICROARRAY TECHNOLOGIES
INTRODUCTION
FIGURE 3 MICROARRAY FEATURE DENSITY
FIGURE 4 MICROARRAY RESOLUTION
TABLE 14 MICROARRAY GENOME CONTENT
TABLE 15 DNA MICROARRAY PLATFORM FEATURES
TABLE 16 DNA MICROARRAY PLATFORM COMPARISON FOR MAJOR MANUFACTURERS
STEPS IN THE DNA MICROARRAY EXPERIMENT
DNA MICROARRAY APPLICATIONS
TABLE 17 DNA MICROARRAY APPLICATIONS
Gene Expression Profiling
TABLE 18 PROBES FOR GENE EXPRESSION DNA MICROARRAYS
TABLE 19 EXAMPLE APPLICATIONS OF GENE EXPRESSION PROFILING
FIGURE 5 GENETIC ANALYSIS TECHNOLOGY COMPETITIVE SPACE
TABLE 20 GENETIC ANALYSIS TECHNOLOGIES COMPARISON
FIGURE 6 RELATIVE NUMBER OF DISEASE-CAUSING ALLELES AT MAF5 AND MAF1
FIGURE 7 COMPETITIVE SPACE FOR GENE EXPRESSION ANALYSIS
FIGURE 8 APPLICATIONS SPACE WITH INTENSE TECHNOLOGY COMPETITION
TABLE 21 PLATFORMS FOR HIGH-THROUGHPUT QUANTITATIVE GENE EXPRESSION ANALYSIS
TABLE 22 GENE EXPRESSION PLATFORMS OF TWO LEADING DNA ARRAY MANUFACTURERS
TABLE 23 PROBE SENSITIVITY AND SPECIFICITY
SNP Analysis
FIGURE 9 SNP ANALYSIS PLATFORMS
Epigenetic Analysis
FIGURE 10 EPIGENOMICS WITHIN THE MOLECULAR BIOLOGY PARADIGM
DNA Methylation
FIGURE 11 EPIGENETIC CHANGES TO DNA AFFECT GENE EXPRESSION
Histones
FIGURE 12 HISTONE TAIL REGIONS MODIFIED BY HAT AND HDAC
DNA Methylation and Histone Analysis Workflow
FIGURE 13 UPSTREAM AND DOWNSTREAM STEPS IN EPIGENETIC ANALYSIS
DNA Methylation Microarrays
ChIP-on-Chip
TABLE 24 CHIP ASSAYS
TABLE 25 TECHNOLOGIES FOR MAPPING GENOMIC LOCATION OF CHROMATIN PROTEINS AND ENZYMES
TABLE 26 PLATFORMS FOR HIGH DENSITY OLIGONUCLEOTIDE EPIGENETICS ARRAYS
Cytogenetic Analysis
TABLE 27 COMPARISON OF CHROMOSOMAL CHANGE DETECTION TECHNOLOGIES
FIGURE 14 COMPETITIVE SPACE FOR CNV ANALYSIS
TABLE 28 CGH MICROARRAY PROBE PLATFORMS
TABLE 29 CGH MICROARRAY TRENDS
TABLE 30 FUTURE TECHNOLOGY NEEDS FOR CGH MICROARRAYS
miRNA Analysis
TABLE 31 WORKFLOW FOR AN MIRNA EXPERIMENT
TABLE 32 TECHNICAL CHALLENGES FOR MIRNAS
ARRAYS ON BEADS
TABLE 33 ARRAYS ON BEADS VERSUS PLANAR MICROARRAYS
CATALOG AND CUSTOM DNA MICROARRAYS
SUPPLY OF REAGENTS AND SAMPLE PREPARATION FOR MICROARRAYS
TOXICOGENOMICS
DNA SEQUENCING
FIGURE 15 COMPARISON OF SANGER WITH UHTS DNA SEQUENCING TECHNOLOGIES
TABLE 34 SMS TECHNOLOGY
TABLE 35 COMPARISON OF SELECTED DNA SEQUENCING PLATFORMS
FIGURE 16 COMPETITIVE SPACE FOR HIGH-THROUGHPUT GENOMIC ANALYSIS
TABLE 36 BIOCHIP CONTENT IN NHGRI GRANTEES FOR NEXT-GENERATION DNA SEQUENCING, 2005
TABLE 37 NEXT-GENERATION DNA SEQUENCING COMPANIES
RESEQUENCING APPROACHES IN DIAGNOSTICS
DNA MICROARRAY MANUFACTURING
FIGURE 17 DNA MICROARRAY MANUFACTURING TECHNOLOGIES
TABLE 38 DNA MICROARRAY PROBE DENSITY TRENDS, FEATURES PER CHIP, 1996--2009
DNA MICROARRAY TECHNOLOGY TRENDS
DNA MICROARRAY TECHNOLOGY CHALLENGES
FIGURE 18 DNA MICROARRAY COST-VOLUME CURVE
PROTEIN MICROARRAY TECHNOLOGIES
INTRODUCTION
FIGURE 19 IMPORTANCE OF PROTEINS
PROTEOMICS WORKFLOW
FIGURE 20 PROTEIN ANALYSIS APPROACHES CONTRASTED
PROTEIN MICROARRAY DESIGN FEATURES
TABLE 39 PROTEIN MICROARRAY PLATFORMS
PROTEIN MICROARRAY APPLICATIONS AS RESEARCH TOOLS
TABLE 40 PROTEIN MICROARRAYS AS RESEARCH TOOLS
PROTEIN MICROARRAY TYPES
TABLE 41 PROTEIN MICROARRAY PRODUCT TYPES
PROTEIN MICROARRAY TECHNOLOGY CHALLENGES
TABLE 42 PROTEIN MICROARRAY TECHNICAL CHALLENGES
PROTEIN MICROARRAY TECHNOLOGY TRENDS
TABLE 43 PROTEIN MICROARRAY TECHNOLOGY TRENDS
EMERGING MICROARRAY TECHNOLOGIES
TABLE 44 EMERGING MICROARRAY TECHNOLOGIES
GLYCOMICS MICROARRAYS
TMAS
FCMS
TABLE 45 U.S. GOVERNMENT INITIATIVES PROMOTING EMERGING MICROARRAYS
MICROARRAY TECHNOLOGY TRENDS
TABLE 46 MICROARRAY TECHNOLOGY TRENDS

Chapter-5: LOAC TECHNOLOGIES

INTRODUCTION
TABLE 47 MICROFLUIDICS PRODUCT LIFE CYCLE STAGE
TABLE 48 LOAC SUBSTRATE TECHNOLOGIES
LOAC TYPES
TABLE 49 LOAC TYPES
IN VITRO PROTEOMICS
ELECTROPHORESIS ON A CHIP
STRUCTURAL PROTEOMICS
PCR ON A CHIP
IMMUNOASSAYS ON A CHIP
TABLE 50 IMMUNOASSAY-ON-A-CHIP APPLICATIONS
LOAC APPLICATIONS
TABLE 51 LOAC MARKET SEGMENTS
TABLE 52 MICROFLUIDIC SYSTEMS ADVANTAGES FOR BIOCHEMICAL ANALYSIS
LOAC KEY TECHNOLOGY TRENDS
TABLE 53 LOAC KEY TECHNOLOGY TRENDS
TABLE 54 LOAC TECHNOLOGY PLATFORMS
LOAC TECHNOLOGY CHALLENGES
TABLE 55 LOAC TECHNOLOGY CHALLENGES

Chapter-6: BIOCHIP APPLICATIONS IN DRUG DISCOVERY AND DEVELOPMENT

BIOCHIP MARKET SEGMENTATION
TABLE 56 BIOCHIP KEY LIFE SCIENCES MARKET SEGMENTS
DRUG DISCOVERY AND DEVELOPMENT
TABLE 57 DRUG R&D INVESTMENT BY STAGE, 2003 (%)
DRUG INDUSTRY CHALLENGES
OVERVIEW OF THE DRUG DISCOVERY AND DEVELOPMENT PROCESS
FIGURE 21 DRUG DISCOVERY AND DEVELOPMENT TIMESCALE
TABLE 58 BIOCHIP APPLICATIONS IN DRUG DISCOVERY AND DEVELOPMENT
DRUG TARGET IDENTIFICATION
DRUG DISCOVERY
Structural Biology
Lead Generation
Lead Optimization
Process R&D
Preclinical and Clinical Trials
NEEDS IN THE DRUG DISCOVERY AND DEVELOPMENT PROCESS
TABLE 59 KEY NEEDS IN DRUG DISCOVERY AND DEVELOPMENT
FIGURE 22 VALIDATION GAP FOR FUTURE DRUG TARGETS (NUMBER OF POTENTIAL DRUG TARGETS)

Chapter-7: BIOCHIP APPLICATIONS IN DIAGNOSTICS

INTRODUCTION
DRIVING FORCES FOR ADOPTION OF BIOCHIP DIAGNOSTIC PLATFORMS
BIOMARKER DISCOVERY AND VALIDATION
CLINICAL ACCEPTANCE OF BIOMARKER-BASED TESTS
TABLE 60 RATE OF ADOPTION OF DNA MICROARRAY DIAGNOSTICS TESTS
MICROARRAY STANDARDIZATION EFFORTS
Microarray Quality Control Project
External RNA Controls Consortium (ERCC) Study
Association of Bimolecular Resource Facilities (ABRF) CGH Microarray Platform Study
TABLE 61 COMPARISON OF ARRAY-CGH PLATFORMS
OVERVIEW OF MDX
INTRODUCTION
BENEFITS OF BIOCHIPS AS AN MDX PLATFORM
FIGURE 23 BIOCHIPS TARGET HIGH GROWTH, HIGH MARGIN PORTION OF THE IVD MARKET
TABLE 62 BIOTECHNOLOGY DRUGS APPROVED BY THE FDA, 1980--2008 (NUMBER)
PHARMACOGENOMICS TESTS
STRATEGIES FOR COMMERCIALIZING PGX TESTS
MDX MARKET PENETRATION CHALLENGES
TABLE 63 COMPARISON OF DNA-BASED MDX PLATFORMS
TABLE 64 FACTORS AFFECTING PENETRATION OF BIOCHIPS INTO THE MDX MARKET
MDX MARKET SEGMENTS
MDX TEST SENSITIVITY AND SPECIFICITY
FIGURE 24 SENSITIVITY AND SPECIFICITY
STATUS OF BIOCHIPS DIAGNOSTICS BY INDICATION
SUMMARY OF BIOCHIPS DIAGNOSTICS
CANCER OVERVIEW
TABLE 65 U.S. INCIDENCE AND TREATMENT DECISIONS FOR SELECTED CANCERS, 2009
HEMATOLOGICAL CANCERS
BLADDER CANCER
BREAST CANCER
Breast Cancer Screening
Prognosis and Pharmacogenetics Tests
FIGURE 25 BREAST CANCER TREATMENT DECISION TREE FOR ONCOTYPE DX
TABLE 66 ESTIMATED NUMBER OF ANNUAL BREAST CANCER TREATMENT DECISIONS IN THE U.S. BY CANCER CLASSIFICATION
Breast Cancer MDx Platforms
TABLE 67 BREAST CANCER MDX TECHNOLOGY PLATFORMS
Breast Cancer Multivariate Diagnostic Tests
TABLE 68 COMMERCIAL LANDSCAPE FOR MULTIVARIATE BREAST CANCER TESTS, BY PARAMETER
Regulatory Status of Gene Profiling Diagnostic Tests
TABLE 69 FDA REGULATORY POSITION ON IVDMIA
CERVICAL CANCER
TABLE 70 COMMERCIAL LANDSCAPE FOR HPV TESTS
COLORECTAL CANCER
Conventional Colorectal Cancer Screening Tests
TABLE 71 CURRENT SCREENING AND DIAGNOSTICS TESTS FOR COLORECTAL CANCER
Molecular Colorectal Cancer Diagnostics Tests
TABLE 72 COMMERCIAL LANDSCAPE FOR COLORECTAL MOLECULAR TESTS
CUP
TABLE 73 COMMERCIAL MDX PLATFORMS FOR TISSUE OF ORIGIN TESTS
GASTRIC CANCER
LUNG CANCER
OVARIAN CANCER
TABLE 74 OVARIAN CANCER SCREENING TESTS
TABLE 75 OVARIAN CANCER DIAGNOSTIC TEST STATUS
PANCREATIC CANCER
PEDIATRIC CANCERS
PROSTATE CANCER
COMPREHENSIVE CANCER TESTS
STATUS OF BIOCHIP-BASED INFECTIOUS DISEASE DIAGNOSTICS
SEPSIS
TUBERCULOSIS
MRSA
INFLUENZA
OTHER INFECTIOUS DISEASES
STATUS OF BIOCHIP-BASED DME DIAGNOSTICS
DMES
TABLE 76 MICROARRAY-BASED DME DIAGNOSTICS TESTS
WARFARIN DOSING
TABLE 77 WARFARIN CYP PGX DIAGNOSTICS TEST COMPETITOR SPACE
TABLE 78 CYP450 GENE FAMILY PHARMACOGENETIC DIAGNOSTIC GLOBAL TEST MARKET POTENTIAL, 2009 ($ MILLIONS)
STATUS OF BIOCHIP-BASED NEUROLOGICAL DIAGNOSTICS
ALZHEIMERS DISEASE
SCHIZOPHRENIA
STATUS OF BIOCHIP-BASED HEART DISEASE DIAGNOSTICS
CHF FAILURE
TABLE 79 BNP MDX TESTS FOR CHF
OTHER CARDIAC DIAGNOSTICS
STATUS OF BIOCHIP-BASED DIAGNOSTICS FOR CF
TABLE 80 CF BIOCHIP DIAGNOSTIC PLATFORMS
STATUS OF BIOCHIP-BASED DIAGNOSTICS FOR PRE- AND POST-NATAL
STATUS OF BIOCHIP-BASED DIAGNOSTICS FOR IMMUNE DISEASES
HLA TYPING TESTS
AUTOIMMUNE TESTING
STATUS OF BIOCHIP-BASED DIAGNOSTICS FOR FOOD SAFETY/QC
TABLE 81 BIOCHIPS STATUS IN FOOD SAFETY/QC MARKET

Chapter-8: BIOCHIP MARKET GROWTH DRIVING FORCES

INTRODUCTION
FIGURE 26 GROWTH IN SCIENTIFIC PUBLICATIONS RELATED TO MICROARRAYS AND LAB ON A CHIP, 2000--2009 (NUMBER OF PUBMED CITATIONS)
BIOCHIP GROWTH DRIVING FORCES
TABLE 82 PRIMARY FORCES DRIVING OVERALL BIOCHIPS GROWTH
FUNDING FOR LIFE SCIENCE RESEARCH
TABLE 83 STIMULUS FUNDING ALLOCATED TO U.S. SCIENCE SPENDING, 2009 ($ MILLIONS)
FIGURE 27 NIH ANNUAL FUNDING BUDGET, 2000--2009 ($ BILLIONS)
LARGE-SCALE GENOMIC, PROTEOMIC, AND BIOCHIP INITIATIVES
TABLE 84 RESEARCH INITIATIVES DRIVING BIOCHIP GROWTH, 1999--2008
NEED FOR MORE EFFICIENT DRUG DISCOVERY AND DEVELOPMENT PROCESS
GROWTH IN PERSONALIZED MEDICINE
NEED FOR EARLY DETECTION OF CANCERS
AGING POPULATIONS
NEW DISCOVERIES IN GENOMICS AND PROTEOMICS
MINIATURIZATION OF BIOCHIPS
DECLINE IN GENETIC ANALYSIS COSTS
DISCOVERY OF GENE- AND SNP-DISEASE ASSOCIATIONS

Chapter-9: BIOCHIP MARKETS

GLOBAL BIOCHIP MARKET
TABLE 85 GLOBAL VALUE OF BIOCHIP PRODUCTS BY TYPE, THROUGH 2014 ($ MILLIONS)
TABLE 86 GLOBAL VALUE OF BIOCHIP MARKET BY END USE, THROUGH 2014 ($ MILLIONS)
MICROARRAY MARKETS
TABLE 87 GLOBAL VALUE OF MICROARRAYS BY TYPE, THROUGH 2014 ($ MILLIONS)
DNA MICROARRAY MARKETS
DNA MICROARRAY MARKET BY APPLICATION
TABLE 88 GLOBAL VALUE OF DNA MICROARRAYS BY APPLICATION, THROUGH 2014 ($ MILLIONS)
FIGURE 28 ENTRIES TO MIRNA DATABASE, 2002--2009 (NUMBER)
TABLE 89 GLOBAL VALUE OF GENOTYPING DNA MICROARRAYS BY APPLICATION, THROUGH 2014 ($ MILLIONS)
DNA MICROARRAY MARKET BY END-USE INDUSTRY
TABLE 90 GLOBAL VALUE OF DNA MICROARRAYS BY END USE, THROUGH 2014 ($ MILLIONS)
DNA MICROARRAY MARKET BY FORMAT
TABLE 91 GLOBAL VALUE OF DNA MICROARRAYS BY FORMAT, THROUGH 2014 ($ MILLIONS)
BIOCHIPS DIAGNOSTICS MARKETS
BIOCHIPS DIAGNOSTIC MARKET BY APPLICATION
TABLE 92 GLOBAL VALUE OF DIAGNOSTIC BIOCHIPS BY APPLICATION, THROUGH 2014 ($ MILLIONS)
BIOCHIP DIAGNOSTICS MARKET BY BIOCHIP TYPE
TABLE 93 GLOBAL VALUE OF DIAGNOSTIC BIOCHIPS BY TYPE, THROUGH 2014 ($ MILLIONS)
CANCER DIAGNOSTICS BIOCHIPS MARKET BY INDICATION
TABLE 94 GLOBAL VALUE OF CANCER DIAGNOSTIC BIOCHIPS BY INDICATION, THROUGH 2014 ($ MILLIONS)
CANCER DIAGNOSTICS BIOCHIPS MARKET BY BIOCHIP TYPE
TABLE 95 GLOBAL VALUE OF CANCER DIAGNOSTIC BIOCHIPS BY TYPE, THROUGH 2014 ($ MILLIONS)
TABLE 96 ADOPTION RATE FOR DNA MICROARRAYS IN DIAGNOSTICS
DIAGNOSTIC DNA MICROARRAYS MARKET BY ANALYSIS METHOD
TABLE 97 GLOBAL VALUE OF DIAGNOSTIC DNA MICROARRAYS BY ANALYSIS METHOD, THROUGH 2014 ($ MILLIONS)
DIAGNOSTIC DNA MICROARRAYS MARKET BY DIAGNOSTIC FUNCTION
TABLE 98 GLOBAL VALUE OF DNA MICROARRAYS DIAGNOSTICS BY DIAGNOSTIC FUNCTION, THROUGH 2014 ($ MILLIONS)
DIAGNOSTIC PROTEIN MICROARRAY MARKET BY TECHNOLOGY
TABLE 99 GLOBAL VALUE OF PROTEIN MICROARRAY DIAGNOSTICS MARKET BY TECHNOLOGY, THROUGH 2014 ($ MILLIONS)
PROTEIN MICROARRAYS MARKETS
PROTEIN MICROARRAYS MARKETS BY TECHNOLOGY
TABLE 100 GLOBAL VALUE OF PROTEIN MICROARRAYS BY TECHNOLOGY, THROUGH 2014 ($ MILLIONS)
PROTEIN MICROARRAYS MARKET BY PRODUCT FORMAT
TABLE 101 GLOBAL VALUE OF PROTEIN MICROARRAYS BY PRODUCT FORMAT, THROUGH 2014 ($ MILLIONS)
TABLE 102 COATED MICROARRAY SLIDE MARKET PRINCIPAL COMPETITORS
PROTEIN MICROARRAYS MARKET BY END-USE INDUSTRY
TABLE 103 GLOBAL VALUE OF PROTEIN MICROARRAYS BY END USE, THROUGH 2014 ($ MILLIONS)
EMERGING MICROARRAYS MARKETS
EMERGING MICROARRAYS MARKET BY TECHNOLOGY
TABLE 104 GLOBAL VALUE OF EMERGING MICROARRAYS BY TECHNOLOGY, THROUGH 2014 ($ MILLIONS)
EMERGING MICROARRAYS MARKETS BY END-USE INDUSTRY
TABLE 105 GLOBAL VALUE OF EMERGING MICROARRAYS BY END-USE INDUSTRY, THROUGH 2014 ($ MILLIONS)
LOAC MARKETS
VALUE OF LOAC DEVICES BY END-USE INDUSTRY
TABLE 106 GLOBAL VALUE OF LOAC DEVICES BY END-USE INDUSTRY, THROUGH 2014 ($ MILLIONS)
LOAC DRUG DISCOVERY AND DEVELOPMENT MARKET BY APPLICATION
TABLE 107 GLOBAL VALUE OF LOAC DRUG DISCOVERY AND DEVELOPMENT MARKET BY APPLICATION, THROUGH 2014 ($ MILLIONS)
LOAC DIAGNOSTICS MARKET BY APPLICATION
TABLE 108 GLOBAL VALUE OF LOAC DEVICES DIAGNOSTICS MARKET BY APPLICATION, THROUGH 2014 ($ MILLIONS)
BIOCHIPS GEOGRAPHIC MARKETS
GLOBAL VALUE OF BIOCHIPS PRODUCTS BY GEOGRAPHY
TABLE 109 GLOBAL VALUE OF BIOCHIP PRODUCTS BY GEOGRAPHY, THROUGH 2014 ($ MILLIONS)
MICROARRAY GEOGRAPHICAL MARKETS
TABLE 110 GLOBAL VALUE OF DNA MICROARRAYS BY GEOGRAPHIC REGION, THROUGH 2014 ($ MILLIONS)
TABLE 111 GLOBAL VALUE OF PROTEIN MICROARRAYS BY GEOGRAPHIC REGION, THROUGH 2014 ($ MILLIONS)
TABLE 112 GLOBAL VALUE OF EMERGING MICROARRAYS BY GEOGRAPHIC REGION, THROUGH 2014 ($ MILLIONS)
LOAC GEOGRAPHICAL MARKETS
TABLE 113 GLOBAL VALUE OF LOAC BY GEOGRAPHIC REGION, THROUGH 2014 ($ MILLIONS)

Chapter-10: INDUSTRY DYNAMICS

INTRODUCTION
RECENT ACQUISITIONS IN THE BIOCHIP INDUSTRY
TABLE 114 KEY ACQUISITIONS IN BIOCHIP INDUSTRY, 2007--2009
DNA MICROARRAYS COMPETITIVE LANDSCAPE
TABLE 115 LEADING DNA MICROARRAY SUPPLIERS
SOURCES OF COMPETITIVE ADVANTAGE IN DNA MICROARRAYS
TABLE 116 DNA MICROARRAY AND SEQUENCING COMPETITOR STRENGTHS AND WEAKNESSES
NEXT GENERATION SEQUENCING COMPETITIVE LANDSCAPE
TABLE 117 NUMBER OF SECOND-GENERATION GENOME SEQUENCING INSTRUMENTS AT MAJOR SEQUENCING CENTERS, 2009
DIAGNOSTICS BIOCHIP STRATEGIC ALLIANCES
TABLE 118 BIOCHIP STRATEGIC ALLIANCES IN DIAGNOSTICS
PROTEIN MICROARRAY SUPPLIERS
TABLE 119 PROTEIN AND SPECIALTY MICROARRAY SUPPLIERS BY MICROARRAY TECHNOLOGY
LOAC COMPETITIVE LANDSCAPE
TABLE 120 LOAC COMPETITOR LANDSCAPE, BY COMPANY

Chapter-11: PATENTS

INTRODUCTION
BIOCHIP INDUSTRY PATENT STATUS
FIGURE 29 ANNUAL ISSUED DNA MICROARRAY PATENTS BY REGION, 2001--2009 (NUMBER)
FIGURE 30 ANNUAL ISSUED PROTEIN MICROARRAY PATENTS BY REGION, 2001--2009 (NUMBER OF PATENTS GRANTED)
FIGURE 31 ANNUAL ISSUED LOAC PATENTS BY GEOGRAPHY, 2001--2009 (NUMBER)
BIOCHIP COMPANY PATENT STATUS
TABLE 121 ISSUED PATENTS AND PATENT APPLICATIONS FOR SELECTED MICROARRAY COMPANIES (NUMBER)
FIGURE 32 ISSUED PATENTS AND PATENT APPLICATIONS FOR SELECTED MICROARRAY COMPANIES, BY REGION (NUMBER)
TABLE 122 ISSUED PATENTS AND PATENT APPLICATIONS FOR SELECTED LOAC COMPANIES (NUMBER)
FIGURE 33 ISSUED PATENTS AND PATENT APPLICATIONS FOR SELECTED LOAC COMPANIES (NUMBER)
BIOCHIP PATENT LITIGATION STATUS
TABLE 123 STATUS OF LIGITATION ISSUES IN THE BIOCHIP INDUSTRY
INDIVIDUAL PATENT STATUS OF SELECTED BIOCHIP COMPANIES
AFFYMETRIX POSITION
COMBIMATRIX POSITION
ILLUMINA POSITION
CALIPER POSITION
ROCHE-NIMBLEGEN POSITION

Chapter-12: COMPANY PROFILES

20/20 GENE SYSTEMS, INC.
ABBOTT LABORATORIES
ABTECH SCIENTIFIC, INC.
ADVANCED LIQUID LOGIC, INC.
AFFYMETRIX, INC.
TABLE 124 AFFYMETRIX STRATEGIC ALLIANCES
AGENDIA BV
TABLE 125 AGENDIA MICROARRAY-BASED DIAGNOSTICS PIPELINE
AGILENT TECHNOLOGIES, INC.
TABLE 126 AGILENT ACQUISITIONS, 2007--2009
AGNITIO SCIENCE AND TECHNOLOGY
ALLEGRO DIAGNOSTICS, INC.
ALMAC GROUP, LTD.
APPLIED MICROARRAYS, INC.
ARRAYIT CORP.
ARRAYJET, LTD.
ARRAYON BIOTECHNOLOGY
ASPER BIOTECH
ASTERAND
AUSHON BIOSYSTEMS, INC.
AUTOGENOMICS, INC.
TABLE 127 AUTOGENOMICS MICROARRAY-BASED DIAGNOSTICS PIPELINE
AYANDA BIOSYSTEMS S.A.
BAYER AG
TABLE 128 CELL LYSATE MICROARRAYS VERSUS WESTERN BLOT
BECTON DICKINSON
BIACORE AB
BIOCARTIS S.A.
BIODOT, INC.
BIOLOC, LLC
BIOMICRO SYSTEMS, INC.
BIO-RAD LABORATORIES, INC.
BIOSITE, INC.
BIOTHERANOSTICS
BIOTRAY
BIOTROVE, INC.
BLUEGNOME, LTD.
BODITECH MED, INC.
CALIPER LIFE SCIENCES
CAPITALBIO CORP.
CELLECTRICON AB
CELLIX, LTD.
CELL-KINETICS, LTD.
CEPHEID
TABLE 129 COMMERCIAL STATUS OF CEPHEID CLINICAL DIAGNOSTIC TESTS BASED ON XPERT AND SMARTCYCLER PLATFORMS
CLAROS DIAGNOSTICS
CLONTECH LABORATORIES
COMBIMATRIX CORP.
TABLE 130 COMBIMATRIX DNA MICROARRAY PLATFORMS
TABLE 131 COMBIMATRIX DNA MICROARRAY-BASED LAUNCHED DIAGNOSTICS
COVENTOR, INC.
CRYSTAL VISION MICROSYSTEMS S.A.
CYCLOFLUIDIC
DEBIOTECH S.A.
DIAGENIC ASA
TABLE 132 DIAGENIC PATENT PORTFOLIO
DIAGNOSWISS S.A.
DNAVISION S.A.
DYCONEX AG
ECOARRAY, INC.
EDEL THERAPEUTICS S.A.
EKSIGENT TECHNOLOGIES
EPIGEM, LTD.
EXIQON A/S
EXONHIT THERAPEUTICS S.A.
TABLE 133 EXONHIT’S SPLICE-ARRAY DIAGNOSTICS PIPELINE
FEBIT BIOTECH GMBH
FLUIDIGM CORP.
FLUIGENT
FLUXION BIOSCIENCES INC.
GE HEALTHCARE LIFE SCIENCES, LTD.
GENETIX, LTD.
GENEWAVE S.A.S.
GENOMICS USA, INC.
GENPROBE, INC.
GENTEL BIOSCIENCES, INC.
GLYCOMINDS, LTD.
GRACE BIO-LABS, INC.
GREINER BIO-ONE GMBH
TABLE 134 GREINER BIO-ONE BIOCHIP-BASED DIAGNOSTICS PIPELINE
GYROS AB
HANDYLAB, INC.
HIGH THROUGHPUT GENOMICS, INC.
HOLOGIC, INC.
IBIDI GMBH
ICX TECHNOLOGIES
ILLUMINA, INC.
TABLE 135 ILLUMINA SEQUENCING TECHNOLOGY SPACE
IMMUCOR, INC.
INDEVR, INC.
INVERNESS MEDICAL INNOVATIONS, INC.
IRIS BIOTECHNOLOGIES
JOHNSON & JOHNSON AMIC AB
KINEXUS BIOINFORMATICS CORP.
LC SCIENCES
LIFE BIOSCIENCE, INC.
LIFE TECHNOLOGIES, INC.
LUMINEX
TABLE 136 LUMINEX MDX PIPELINE
TABLE 137 LUMINEX PARTNER SUMMARY
MICRALYNE, INC.
MICROCHIPS, INC.
MICROFLUIDIC SYSTEMS, INC.
MICROLIQUID
MICRONICS, INC.
MICRONIT MICROFLUIDICS
MICROPLUMBERS MICROSCIENCES, LLC
MILLIPORE
MOBIDIAG, LTD.
MOLECULAR PROFILING INSTITUTE
NANOSPHERE
NANOSURFACE BIOSCIENCES
NUVERA BIOSCIENCES
OCIMUM BIOSOLUTIONS, LTD.
ORIGENE TECHNOLOGIES, INC.
OSMETECH MOLECULAR DIAGNOSTICS
OY JURILAB, LTD.
PAMGENE INTERNATIONAL B.V.
PANAGENE, INC.
PATHWORK DIAGNOSTICS
PEPSCAN PRESTO B.V.
PERKINELMER
PERLEGEN SCIENCES, INC.
PROMEGA CORP.
PROTAGEN AG
QUANTRX BIOMEDICAL CORP.
QUEST DIAGNOSTICS
RANDOX LABORATORIES, LTD.
TABLE 138 RANDOX BIOCHIPS ASSAYS PORTFOLIO
ROCHE LIFE SCIENCES
SEQUENOM, INC.
SCHOTT JENA GLASS GMBH
SIEMENS AG
SIGMA ALDRICH CORP.
TABLE 139 SIGMA ALDRICH ACQUISITIONS, 2006--2009
SIGNATURE GENOMIC LABORATORIES, LLC
SIRS-LAB GMBH
SPINX TECHNOLOGIES
SQI DIAGNOSTIC SYSTEMS
STMICROELECTRONICS
SUPERBIOCHIP LABORATORIES
SURMODICS, INC.
TESSARAE
THINXXS MICROTECHNOLOGY AG
TRANSLUME, INC.
VEREDUS LABORATORIES PTE, LTD.
VERENIUM CORP.
WASATCH MICROFLUIDICS
WEIDMAN PLASTICS TECHNOLOGIES
WETWARE CONCEPTS S.R.L.
XCEED MOLECULAR
XENOPORE
ZEPTOSENS AG