SPI Infoamtion

Preface

Chapter 1: Introduction to Toxicology and its Outsourcing
Pre-Industrial Toxicology
Toxicology & the Chemical Industrial Revolution
Toxicity Testing
Toxicology Terminology

Chapter 2: Principles and Practices in Outsourcing Toxicology
Introduction
How to Outsource
Essentials of a Contract
Negotiation

Chapter 3: Outsourcing of Toxicology - A Potted History
Covance Inc
Life Science Research Inc (Huntingdon Laboratories)
Charles River
Harlan
NOTOX
Sequani
Laboratory of Pharmacology & Toxicology (LPT)
CIT

Chapter 4: Review of Selected Major CROs

Chapter 5: Summary of the Regulatory Environment
USA
Europe
Japan
Good Laboratory Practice (GLP)
GLP & Outsourcing

Chapter 6: The Preclinical Market
REACH
Preclinical CROs by Country
Rate of Formation of Toxicology CROs
Market Size Analysis

Chapter 7: The Use of Non Animal Testing in Toxicology
Introduction
Validation Organisations
Validation Studies
The Validation Process

Chapter 8: Conclusions and Future Challenges
Introduction
Technical Challenges
Genomics
Proteomics
Metabolomics
Biomarkers
Biopharmaceuticals
Political Challenges
Afterword

Appendix: Profiles of Preclinical and Toxicology CROs
Accelera (Italy)
Advinus (India)
Aptuit (USA)
Charles River (Edinburgh)
CIT (France)
Covance (USA)
Harlan (USA) (Including SafePharm (UK) and RCC (Switzerland})
LSR (Huntingdon)
ITR (Canada)
LAB Research (Including ScanTox (Denmark) and TRC Hungary)
Laboratory of Pharmacology and Toxicology (Germany)
Maccine (Singapore)
MPI (USA)
NOTOX (Netherlands)
Quotient Bioresearch (UK)
Ricerca (USA)
Sequani (UK)
TNO (Netherlands)
WIL (USA)
WuXi (China)