SPI Infoamtion

Table of Contents

1. Executive Summary
1.1 Monoclonal Antibodies in Cancer Therapy: Market Review
1.2 Aims, Scope and Format of the Report
1.3 Research & Analysis Methods

2. Introduction to Monoclonal Antibodies for Cancer Therapy
2.1 Oncology is the Fifth-Largest Therapeutic Class Worldwide by Total Sales
2.2 The Oncology Market is Growing
2.3 Monoclonal Antibodies
2.3.1 What are Monoclonal Antibodies?
2.3.2 How do Monoclonal Antibody Therapies Work?
2.4 Categories of Monoclonal Antibodies for Therapeutic Use
2.4.1 Murine Antibodies
2.4.2 Chimeric and Humanised Antibodies
2.4.3 Fully Human Antibodies
2.4.4 Immunogenicity
2.5 Current Monoclonal Antibody Cancer Therapies
2.5.1 Avastin
2.5.2 MabThera/Rituxan
2.5.3 Herceptin
2.5.4 Erbitux
2.5.5 Vectibix
2.5.6 Campath
2.5.7 Mylotarg
2.5.8 Zevalin
2.5.9 Bexxar
2.5.10 Arzerra
2.5.11 TheraCIM
2.5.12 Removab

3. Cancer Therapy MAbs: World Market Prospects, 2010-2025
3.1 The Market for Monoclonal Antibodies in Cancer Therapy, 2009
3.2 The Biotech Market is Expanding Rapidly
3.2.1 Monoclonal Antibodies -- Leading Class in the Pharma Biotech Market
3.2.2 Oncology is a Major Sales Driver in the Monoclonal Antibodies Market
3.3 Cancer Therapy MAbs: Market Forecast, 2010-2025
3.4 The Big Three Monoclonal Antibodies in Cancer Therapy
3.5 Generic Competition
3.6 Chimeric Antibodies
3.7 The Shift Towards Human Antibodies

4. The Leading Monoclonal Antibodies in Cancer Therapy, 2010-2025
4.1 The Leading Four Monoclonal Antibodies Accounted for 34% of the Global Cancer Drug Market in 2009
4.2 Avastin (Bevacizumab)
4.2.1 Avastin Leads the Market for Monoclonal Antibodies in Cancer Therapy
4.2.2 Avastin Will Show High Growth -- But Will it Last?
4.3 MabThera/Rituxan (Rituximab)
4.3.1 MabThera/Rituxan Sales Forecast, 2010-2015
4.3.2 Long-Term Prospects for MabThera/Rituxan, 2015-2025
4.3.3 Competition for MabThera/Rituxan
4.3.4 Biosimilar MabThera/Rituxan
4.4 Herceptin (Trastuzumab)
4.4.1 Short Term Forecast for Herceptin
4.4.2 Long Term Prospects for Herceptin, 2015-2025
4.4.3 Herceptin's Major Competitors, 2010-2025
4.5 Erbitux (Cetuximab)
4.5.1 Erbitux Sales Forecast, 2010-2015
4.5.2 Erbitux Sales Forecast, 2015-2025
4.5.3 Erbitux’ Major Competitors, 2010-2025
4.6 Vectibix (Panitumumab)
4.6.1 Vectibix Sales Forecast, 2010-2025
4.7 Campath (Alemtuzumab)
4.7.1 Campath Sales Forecast, 2010-2025
4.8 Chapter Summary -- The Leading Monoclonal Antibodies in Cancer Therapy, 2010-2025

5. SWOT Analysis
5.1 Key Market Drivers
5.1.1 The High Profile of Cancer
5.1.2 The Increasing Prevalence of Cancer
5.1.3 The High Economic Cost of Cancer
5.1.4 Drug Prices
5.1.5 Improvements in Accessibility
5.1.6 Incremental Improvements in Treatment in the Absence of a Complete Cure
5.1.7 New Production Methods Will Reduce Costs
5.1.8 Biologicals versus Chemically-Derived Pharmaceutical Products
5.1.9 Combining Existing Products
5.1.10 Monoclonal Antibodies Have a Lower Risk of Adverse Effects
5.1.11 Promising Pipelines
5.1.12 Personalised Medicine
5.2 Key Market Restraints
5.2.1 High Development Costs
5.2.2 Financial Limitations in Research and Development
5.2.3 Research Bias and 'Me-Too' Drugs
5.2.4 Risk Sharing
5.2.5 Public Health Initiatives
5.2.6 Competition is Fierce for Many Targets
5.2.7 Insufficient Efficacy as Monotherapies
5.2.8 Immunogenicity
5.2.9 Safety Concerns
5.2.10 Mode of Administration is a Limiting Factor
5.2.11 Biosimilar Monoclonal Antibodies

6. Cancer MAbs in the Leading National Pharmaceutical Markets, 2010-2025
6.1 Leading National Markets for Cancer Monoclonal Antibodies, 2009
6.2 National Market Forecasts, 2010-2025
6.3 US Cancer Monoclonal Antibodies Market: Prospects, 2010-2025
6.4 Japanese Cancer Monoclonal Antibodies Market: Prospects, 2010-2025
6.5 Cancer Monoclonal Antibody Markets in the Leading European Countries: Prospects, 2010-2025
6.6 Cancer Monoclonal Antibody Markets in China and India: Prospects, 2010-2025

7. R&D Pipeline for Monoclonal Antibody Cancer Therapies
7.1 New Technology -- Monoclonal Antibody Fragments
7.1.1 Bispecific T-Cell Engagers
7.1.2 Tandabs
7.2 Conjugated versus Naked Antibodies
7.3 The Future of Fully Human MAbs
7.4 Competition for Prime Drug Targets
7.4.1 Tailored Medicine
7.5 Late-Stage Pipeline: Additional and Expanded Indications
7.5.1 Avastin
7.5.2 MabThera/Rituxan
7.5.3 Herceptin
7.5.4 Erbitux
7.6 Late-Stage R&D Pipeline Review
7.6.1 Dalotuzumab
7.6.2 Galiximab
7.6.3 Ipilimumab
7.6.4 Ramucirumab
7.6.5 Zalutumumab

8. Expert Opinions
8.1 Dr Mark Cragg
8.1.1 How Do Monoclonal Antibodies Treat Cancer?
8.1.2 The Future of Different Monoclonal Antibody Types
8.1.3 Threats and Limitations
8.1.4 Opportunities
8.1.5 Will Side Effects Limit Growth?
8.1.6 Future Developments
8.2 Dr Janice M. Reichert
8.2.1 Main Challenges
8.2.2 Main Opportunities
8.2.3 Side Effects
8.2.4 Future Developments and Pipelines
8.2.5 The Effect of Biosimilars

9. Conclusions
9.1 The Monoclonal Antibody Market, 2010-2025
9.2 Sales Growth for Monoclonal Antibody Cancer Therapies
9.3 The Monoclonal Antibody R&D Pipeline for Cancer Treatment
9.4 Expansion into Emerging Markets
9.5 Personalised Treatments
9.6 Future Prospects

List of Tables
Table 2.1 Monoclonal Antibody Technologies -- Overview, 2010
Table 2.2 Targets and Indications for Selected FDA-Approved Antibodies, 2010
Table 3.1 Monoclonal Antibodies in Cancer Therapy: Overall Sales Forecast, 2010-2016
Table 3.2 Monoclonal Antibodies in Cancer Therapy: Overall Sales Forecast, 2017-2025
Table 3.3 Leading MAbs in Cancer Therapy: Sales & Market Shares, 2009, 2015, 2020 & 2025
Table 3.4 Cancer Monoclonal Antibodies: Sales & Market Shares by Class, 2009
Table 4.1 Avastin Sales Forecast, 2010-2016
Table 4.2 Avastin Sales Forecast, 2017-2025
Table 4.3 MabThera Sales Forecast, 2010-2016
Table 4.4 MabThera Sales Forecast, 2017-2025
Table 4.5 Herceptin Sales Forecast, 2010-2016
Table 4.6 Herceptin Sales Forecast, 2017-2025
Table 4.7 Erbitux Sales Forecast, 2010-2016
Table 4.8 Erbitux Sales Forecast, 2017-2025
Table 4.9 Vectibix Sales Forecast, 2010-2016
Table 4.10 Vectibix Sales Forecast, 2017-2025
Table 4.11 Campath Sales Forecast, 2010-2016
Table 4.12 Campath Sales Forecast, 2017-2025
Table 5.1 SWOT Chart for Cancer Monoclonal Antibodies, 2010-2025
Table 5.2 Side Effects of Monoclonal Antibody Therapy, 2010
Table 5.3 The Importance of Personalised Medicine in Oncology, 2010
Table 6.1 Leading National Markets for Cancer MAbs: Sales, 2009
Table 6.2 Leading National Markets for Cancer MAbs: Sales Forecasts, 2010-2016
Table 6.3 Leading National Markets for Cancer MAbs: Sales Forecasts, 2017-2025
Table 6.4 Leading National Markets for Cancer MAbs: Sales & Market Shares, 2009, 2015, 2020 & 2025
Table 7.1 Cancer MAb R&D Pipeline: Promising Agents in Phase III, 2010

List of Figures
Figure 3.1 Market Shares of the Monoclonal Antibody Therapeutic Areas, 2009
Figure 3.2 Sales of the Top Three Monoclonal Antibody Cancer Therapies, 2005-2009
Figure 3.3 Monoclonal Antibodies in Cancer Therapy: Overall Sales Forecast, 2010-2025
Figure 3.4 Leading MAbs in Cancer Therapy: Market Shares, 2009
Figure 3.5 Leading MAbs in Cancer Therapy: Market Shares, 2025
Figure 3.6 MAbs in Cancer Therapy: Market Shares by Class, 2009
Figure 4.1 Avastin Sales Forecast, 2010-2025
Figure 4.2 MabThera Sales Forecast, 2010-2025
Figure 4.3 Herceptin Sales Forecast, 2010-2025
Figure 4.4 Erbitux Sales Forecast, 2010-2025
Figure 4.5 Vectibix Sales Forecast, 2010-2025
Figure 4.6 Campath Sales Forecast, 2010-2025
Figure 4.7 Leading MAbs in Cancer Therapy: Sales, 2009, 2015 & 2025
Figure 4.8 Leading MAbs in Cancer Therapy: Sales Forecasts, 2010-2025
Figure 6.1 Leading National Market Shares, 2009
Figure 6.2 Leading National Market Shares, 2015
Figure 6.3 Leading National Market Shares, 2025
Figure 6.4 US: MAbs in Cancer Therapy Sales Forecast, 2010-2025
Figure 6.5 Japan: MAbs in Cancer Therapy Sales Forecast, 2010-2025
Figure 6.6 Leading European Countries: MAbs in Cancer Therapy Sales Forecasts, 2010-2025
Figure 6.7 China & India: MAbs in Cancer Therapy Sales Forecasts, 2010-2025