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Chapter- 1: INTRODUCTION
STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
INTENDED AUDIENCE
SCOPE OF REPORT
METHODOLOGY
INFORMATION SOURCES
RELATED BCC REPORTS
ANALYST CREDENTIALS
BCC ONLINE SERVICES
DISCLAIMER

Chapter-2: EXECUTIVE SUMMARY
SUMMARY TABLE GLOBAL VALUE OF DNA SEQUENCING PRODUCTS, BY END-USE APPLICATION, THROUGH 2015 ($ MILLIONS)
SUMMARY FIGURE GLOBAL VALUE OF DNA SEQUENCING PRODUCTS, BY END-USE APPLICATION, 2009-2015 ($ MILLIONS)

Chapter-3: OVERVIEW
INTRODUCTION
TABLE 1 SCOPE OF THIS REPORT
MARKET POTENTIAL OF DNA SEQUENCING PRODUCTS
TABLE 2 GLOBAL VALUE OF DNA SEQUENCING WORKFLOW PRODUCTS, BY TYPE, THROUGH 2015 ($ MILLIONS)
SEQUENCING INDUSTRY GROWTH DRIVING FORCES
TABLE 3 DNA SEQUENCING KEY GROWTH DRIVING FORCES
SEQUENCING PRODUCTS
SEQUENCING INSTRUMENTS
SEQUENCING CONSUMABLES
SEQUENCING PRODUCT LIFE CYCLE STATUS
TABLE 4 PRODUCT LIFE CYCLE STATUS OF SEQUENCING PLATFORMS
COMMERCIAL STATUS
SEQUENCING INDUSTRY
TABLE 5 SEQUENCING INSTRUMENT COMPETITORS, BY TECHNOLOGY

Chapter-4: DNA SEQUENCING TECHNOLOGIES
GENETIC ANALYSIS
FIGURE 1 CENTRAL MOLECULAR BIOLOGY DOGMA
FIGURE 2 DNA, MRNA, AND GENETIC VARIATION
TABLE 6 SCOPE OF KEY GENETIC ANALYSIS TECHNOLOGIES
HISTORY OF DNA SEQUENCING
TABLE 7 DNA SEQUENCING HISTORICAL TIMELINE
FIGURE 3 SEQUENCING COST TREND, BASE PAIRS SEQUENCED PER DOLLAR
FIGURE 4 SEQUENCING THROUGHPUT TREND
FIGURE 5 HUMAN GENOME SEQUENCING COST TREND, 2000-2015 (DOLLARS)
FIGURE 6 $1,000 GENOME PRODUCT SPACE
OVERVIEW OF SEQUENCING TECHNOLOGIES
TABLE 8 DNA SEQUENCING TECHNOLOGY PLATFORM COMPARISON
SANGER SEQUENCING
SANGER SEQUENCING TECHNOLOGY
FIGURE 7 DDNTP CHEMICAL STRUCTURE
FIGURE 8 SANGER SEQUENCING WORKFLOW
SANGER SEQUENCING COSTS
FIGURE 9 COST BREAKDOWN FOR SEQUENCING A SINGLE HUMAN GENOME, USING 2005 SANGER SEQUENCER TECHNOLOGY (%)
LIMITATIONS OF SANGER SEQUENCING
TABLE 9 LIMITATIONS OF SANGER SEQUENCING TECHNOLOGY
TECHNOLOGY DEVELOPMENTS IN SANGER SEQUENCING
TABLE 10 IMPROVEMENTS IN SANGER SEQUENCING TECHNOLOGY
NEXT-GENERATION SEQUENCING TECHNOLOGIES
INTRODUCTION
NEXT-GENERATION SEQUENCING WORKFLOW
TABLE 11 NEXT-GENERATION SEQUENCING WORKFLOW STEPS
FIGURE 10 NEXT-GENERATION SEQUENCING TECHNOLOGIES
TABLE 12 WORKFLOW COMPARISON OF SELECTED NEXT-GENERATION DNA SEQUENCING PLATFORMS
TABLE 13 NEXT-GENERATION SEQUENCE PLATFORMS
FIGURE 11 SCHEMATIC COMPARISON OF ROCHE/454, LIFE TECHNOLOGIES, AND ILLUMINA SEQUENCING PLATFORMS
TABLE 14 NEXT-GENERATION SEQUENCING PLATFORM ADVANTAGES AND LIMITATIONS
SEQUENCING BY SYNTHESIS WITH REVERSIBLE TERMINATORS
FIGURE 12 SEQUENCING BY SYNTHESIS: REVERSIBLE TERMINATOR REACTION
PYROSEQUENCING
FIGURE 13 SEQUENCING BY SYNTHESIS: PYROSEQUENCING REACTION
SEQUENCING BY LIGATION
Sample Preparation
Sequencing Reaction
FIGURE 14 SCHEMATIC OF SOLID SEQUENCING BY LIGATION
Cycle 1
Cycle 2
Cycles 3 to 5
Decoding
FIGURE 15 DECODING SOLID COLOR DATA
THIRD-GENERATION SEQUENCING
Single-molecule Sequencing by Synthesis
Nanopore Sequencing
FIGURE 16 SINGLE-MOLECULE SEQUENCING BY SYNTHESIS
FIGURE 17 NANOPORE SEQUENCING WORKFLOW AND TECHNOLOGY APPROACHES
SEQUENCING TECHNOLOGY PLATFORMS COMPARED
TABLE 15 KEY PERFORMANCE METRICS FOR SEQUENCING TECHNOLOGIES
TABLE 16 COST AND PERFORMANCE COMPARISON OF SELECTED NEXT- AND THIRD-GENERATION DNA SEQUENCING PLATFORMS
SEQUENCING PRODUCT LIFE CYCLE
TABLE 17 LIFE CYCLE OF DNA SEQUENCING TECHNOLOGIES
SEQUENCING INSTRUMENT CUMULATIVE INSTALLED BASE
FIGURE 18 GLOBAL CUMULATIVE INSTALLED BASE OF DNA SEQUENCERS, THROUGH APRIL 2010 (%)
SEQUENCE READ LENGTH
TABLE 18 READ LENGTHS FOR SELECTED SEQUENCING PLATFORMS
SEQUENCER PERFORMANCE SPACE
FIGURE 19 SEQUENCING COMPETITIVE MARKET SPACE
END-USER SWITCHING
PAIRED-END READS
TABLE 19 STRENGTHS AND LIMITATIONS OF PAIRED-END READS
BARCODING
DNA POLYMERASES
SEQUENCING BIOINFORMATICS
TABLE 20 INFORMATICS WORKFLOW FOR NEXT-GENERATION SEQUENCING
TECHNOLOGY CHALLENGES FOR NEXT-GENERATION PLATFORMS
TABLE 21 TECHNOLOGY CHALLENGES FOR NEXT-GENERATION SEQUENCING

Chapter-5: DNA SEQUENCING APPLICATIONS
INTRODUCTION
FIGURE 20 WHOLE GENOME SEQUENCING PROJECTS FOR PROKARYOTES AND EUKARYOTES, AS OF APRIL 2010 (NUMBER OF GENOMES SEQUENCED)
FIGURE 21 WHOLE GENOME SEQUENCING EUKARYOTIC PROJECTS, BY TYPE, AS OF APRIL 2010
RESEARCH AND DRUG DISCOVERY APPLICATIONS
INTRODUCTION
TABLE 22 GENETIC ANALYSIS FORMATS COMPARISON
TABLE 23 SEQUENCING APPLICATIONS
TABLE 24 DE NOVO VERSUS RESEQUENCING REQUIREMENTS
DE NOVO SEQUENCING
De Novo Human Sequencing
De Novo Microbial Sequencing
TABLE 25 CASE STUDY 1: NEANDERTHAL DNA SEQUENCING
RESEQUENCING
Whole Genome Resequencing (Genome-wide Association Studies or Loci Discovery)
FIGURE 22 RELATIVE NUMBER OF DISEASE-CAUSING ALLELES AT MAF5 AND MAF1
FIGURE 23 SINGLE SEQUENCER, WHOLE GENOME THROUGHPUT TRENDS 1975-2015
Targeted Resequencing
SEQ-BASED METHODS
TABLE 26 GENETIC ANALYSIS APPLICATIONS WHERE SEQUENCING COMPETES WITH MICROARRAYS
Chromatin Immunoprecipitation Applications
TABLE 27 COMPARISON OF SEQUENCING WITH MICROARRAYS FOR CHIP APPLICATIONS
DNase-seq
Gene Expression Analysis
TABLE 28 COMPARISON OF SEQUENCING AND MICROARRAYS FOR GENE EXPRESSION ANALYSIS
MethylSeq
DNA Mutation Studies
Complementary Sequencing and Microarray Platforms Drive Market Growth
DIAGNOSTICS AND DRUG DISCOVERY
FIGURE 24 APPLICATIONS SPACE WITH INTENSE TECHNOLOGY COMPETITION
FIGURE 25 APPLICATIONS SPACE WITH INTENSE TECHNOLOGY COMPETITION
PERSONAL GENOMICS
FIGURE 26 GENETIC ANALYSIS COST/INFORMATION CONTENT TRENDS

Chapter-6: DNA SEQUENCING INITIATIVES
INTRODUCTION
FIGURE 27 NIH FUNDING AWARDS, BY INSTITUTE, FOR DNA SEQUENCING -- RELATED PROJECTS, 2009-2010 (%)
NHGRI $1,000 GENOME PROJECT FUNDING
TABLE 29 NHGRI GRANTS UNDER $1,000 GENOME PROGRAM, FY2009 ($)
FIGURE 28 NHGRI $1,000 GENOME PROJECT AWARDS VALUE, FY2007- FY2009 ($ MILLIONS)
FIGURE 29 $1,000 GENOME PROJECT AWARDS, BY TECHNOLOGY, 2007-2009 (%)
SEQUENCING-RELATED GENOMICS PROJECTS OVERVIEW AND STATUS
TABLE 30 IMPORTANT SEQUENCING RESEARCH INITIATIVES
GENOME SEQUENCING PROJECTS
Functional Genomics in Norway (FUGE) II
Personal Genome Project
Archon X Prize in Genomics
Genomes 10K Project
1,000 Plant and Animal Reference Project
MEDICAL SEQUENCING PROJECTS
Mapped Autosomal Mendelian Disorders
Allelic Spectrum in Common Disease Program
Clinseq Project
CANCER SEQUENCING PROJECTS
Cancer Genome Project
Tumor Sequencing Project (TSP)
The Cancer Genome Atlas
MICROBIAL SEQUENCING PROJECTS
Human Microbiome Project
Microbial Genome Sequencing Project
Marine Microbial Genome Sequencing Project
Fungal Genome Initiative
Pathogen Sequencing Program
Genomic Encyclopedia of Bacteria and Archaea (GEBA)
Metagenomics of the Human Intestinal Tract (MetaHIT)
Gut Microbiome Initiative
10,000 Microbial Genomes Project
GENOME VARIATION PROJECTS
Encyclopedia of DNA Elements (ENCODE)
1,000 Genomes Project
1,000 Plant Genomes Project
Resequencing Technology Program
Human Genome Structural Variation Project
Yanhuang Project
AGRICULTURAL GENOMICS
National Plant Genome Initiative
EPIGENOMICS SEQUENCING PROJECTS
TABLE 31 EPIGENOMICS INITIATIVES
EUROPE
UNITED STATES
ASIA
IMPACT OF SEQUENCING PROJECTS
FIGURE 30 GROWTH IN BASE PAIRS DEPOSITED IN GENBANK, 1988-2008 (BILLIONS)

Chapter-7: DNA SEQUENCING INDUSTRY STRUCTURE
INDUSTRY STRUCTURE ANALYSIS
FIGURE 31 DNA SEQUENCING INDUSTRY STRUCTURE, 1995-2005
FIGURE 32 DNA SEQUENCING INDUSTRY STRUCTURE: POST 2005
TABLE 32 DNA SEQUENCING INDUSTRY TRANSITION
THE ROLE OF EARLY ADAPTORS
SEQUENCING INSTRUMENT COMPETITOR POSITIONING
FIGURE 33 SEQUENCER PLATFORM POSITIONING BY READS AND READ LENGTH
TABLE 33 SEQUENCING INSTRUMENT COMPETITORS, BY TECHNOLOGY
SEQUENCING SAMPLE PREPARATION INDUSTRY
TABLE 34 POSITIONING OF SEQUENCE ENRICHMENT FORMATS
TABLE 35 SEQUENCING SAMPLE PREPARATION COMPANY POSITIONING
SEQUENCING BIOINFORMATICS INDUSTRY
TABLE 36 DNA SEQUENCING BIOINFORMATICS COMPANY POSITIONING
SEQUENCING SERVICES INDUSTRY
TABLE 37 DNA SEQUENCING SERVICES COMPANY POSITIONING, BY MARKET FOCUS
SEQUENCING INSTRUMENTS COMPETITOR MARKET SHARES
FIGURE 34 ESTIMATED COMPETITOR MARKET SHARE: SEQUENCING INSTRUMENTS AND REAGENTS, 2009 (%)
FIGURE 35 ESTIMATED COMPETITOR MARKET SHARE: SANGER SEQUENCING INSTRUMENTS AND REAGENTS, 2009 (TOTAL MARKET $466.2 MILLION) (%)
FIGURE 36 ESTIMATED COMPETITOR MARKET SHARE: NEXT-GENERATION SEQUENCING INSTRUMENTS AND REAGENTS, 2009 (TOTAL MARKET $607.4 MILLION) (%)
INDUSTRY ACQUISITIONS AND STRATEGIC ALLIANCES
TABLE 38 SEQUENCING INDUSTRY ACQUISITIONS, 2007-2010
TABLE 39 SEQUENCING INDUSTRY STRATEGIC ALLIANCES, 2007-2010
SEQUENCING REAGENTS SUPPLY ALLIANCES
PERSONAL GENOMICS INDUSTRY DYNAMICS
TABLE 40 MEDIUM TO HIGH CONTENT DTC GENETIC TESTING KEY COMPETITORS
FIGURE 37 PERSONAL GENOMICS COMPETITIVE SPACE, BY TEST COST AND SCOPE
TABLE 41 PERSONAL GENOMICS COMPETITOR STRATEGIES
DNA SEQUENCING END USERS
TABLE 42 DNA SEQUENCING END-USER MARKET SEGMENTS
Major Sequencing Centers
TABLE 43 NEXT-GENERATION SEQUENCING INSTRUMENT INSTALLATIONS, BY MAJOR SEQUENCING CENTER, 2010
FIGURE 38 MAJOR SEQUENCING CENTER’S SHARE OF THE GENOME SEQUENCING PROJECTS MARKET BY NUMBER OF SEQUENCING PROJECTS, APRIL 2010 (%)
FIGURE 39 BEIJING GENOMICS INSTITUTE ADOPTION OF NEXT-GENERATION SEQUENCERS, 2008 AND 2010 (NUMBER OF SEQUENCERS)
Large Core Sequencing Centers
TABLE 44 EXAMPLES OF LARGE CORE SEQUENCING CENTERS
Small to Mid-size Laboratories
Sequencing Service Laboratories

Chapter-8: DNA SEQUENCING MARKETS
GROWTH DRIVING FORCES
TABLE 45 DNA SEQUENCING KEY GROWTH DRIVING FORCES
FIGURE 40 EUKARYOTIC SEQUENCING PARADIGM
GENETIC ANALYSIS MARKETS
TABLE 46 GLOBAL VALUE OF GENETIC ANALYSIS MARKET, BY ANALYSIS TYPE, THROUGH 2015 ($ MILLIONS)
FIGURE 41 SNP GENOTYPING MARKET
DNA SEQUENCING PRODUCTS MARKETS
DNA SEQUENCING MARKETS BY PRODUCT TYPE
TABLE 47 GLOBAL VALUE OF DNA SEQUENCING WORKFLOW PRODUCTS, BY TYPE, THROUGH 2015 ($ MILLIONS)
TABLE 48 GLOBAL VALUE OF DNA SEQUENCING INSTRUMENT AND CONSUMABLES MARKET, BY PRODUCT TYPE, THROUGH 2015 ($ MILLIONS)
DNA SEQUENCING MARKETS BY SANGER AND NEXT-GENERATION FORMATS
FIGURE 42 GLOBAL VALUE OF SEQUENCING INSTRUMENTS AND CONSUMABLES, BY TECHNOLOGY PLATFORM, 2010 AND 2015 (DOLLARS)
TABLE 49 GLOBAL VALUE OF DNA SEQUENCING INSTRUMENTS, BY PLATFORM, THROUGH 2015 ($ MILLIONS)
TABLE 50 GLOBAL VALUE OF DNA SEQUENCING CONSUMABLES MARKET, BY PLATFORM, THROUGH 2015 ($ MILLIONS)
DNA SEQUENCING MARKETS BY END USER
TABLE 51 GLOBAL VALUE OF DNA SEQUENCING INSTRUMENTS AND CONSUMABLES, BY CUSTOMER TYPE, THROUGH 2015 ($ MILLIONS)
TABLE 52 GLOBAL VALUE OF SANGER SEQUENCING INSTRUMENTS AND CONSUMABLES, BY CUSTOMER, THROUGH 2015 ($ MILLIONS)
TABLE 53 GLOBAL VALUE OF NEXT-GENERATION SEQUENCING INSTRUMENTS AND CONSUMABLES, BY CUSTOMER, THROUGH 2015 ($ MILLIONS)
DNA SEQUENCING MARKETS BY TECHNOLOGY
TABLE 54 GLOBAL VALUE OF DNA SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY TECHNOLOGY, THROUGH 2015 ($ MILLIONS)
DNA SEQUENCING MARKETS BY END-USER APPLICATION
TABLE 55 GLOBAL VALUE OF DNA SEQUENCING, BY END-USE APPLICATION, THROUGH 2015 ($ MILLIONS)
Research and Drug Discovery and Development
Forensic and Human ID
Bacterial Genomics
Agricultural Genomics
Clinical Diagnostics
TABLE 56 LABORATORIES DEVELOPING NEXT-GENERATION SEQUENCING DX TESTS
Personal Genomics
Other Applications
TABLE 57 GLOBAL VALUE OF NEXT-GENERATION SEQUENCING INSTRUMENTS AND CONSUMABLES, BY END-USE APPLICATION, THROUGH 2015 ($ MILLIONS)
TABLE 58 GLOBAL VALUE OF SANGER SEQUENCING INSTRUMENTS AND CONSUMABLES, BY END-USE APPLICATION, THROUGH 2015 ($ MILLIONS)
DNA SEQUENCING MARKETS BY GENOME TYPE
TABLE 59 GLOBAL VALUE OF SEQUENCING, BY GENOME TYPE, THROUGH 2015 ($ MILLIONS)
DNA SEQUENCING MARKETS BY ANALYSIS TYPE
TABLE 60 GLOBAL VALUE OF DNA SEQUENCING, BY ANALYSIS TYPE, THROUGH 2015 ($ MILLIONS)
TABLE 61 GLOBAL VALUE OF NEXT-GENERATION SEQUENCING, BY ANALYSIS TYPE, THROUGH 2015 ($ MILLIONS)
TABLE 62 GLOBAL VALUE OF SANGER SEQUENCING, BY ANALYSIS TYPE, THROUGH 2015 ($ MILLIONS)
DNA SEQUENCING MARKETS BY GEOGRAPHY
TABLE 63 GLOBAL VALUE OF DNA SEQUENCING PRODUCTS, BY GEOGRAPHICAL MARKET, THROUGH 2015 ($ MILLIONS)
TABLE 64 GLOBAL VALUE OF SANGER SEQUENCING PRODUCTS, BY GEOGRAPHICAL MARKET, THROUGH 2015 ($ MILLIONS)
TABLE 65 GLOBAL VALUE OF NEXT-GENERATION SEQUENCING PRODUCTS, BY GEOGRAPHICAL MARKET, THROUGH 2015 ($ MILLIONS)

Chapter-9: DNA SEQUENCING PATENT STATUS
RECENT PATENT ACTIVITY IN NEXT-GENERATION DNA SEQUENCING
TABLE 66 NEXT-GENERATION SEQUENCING PATENT RECENT ACTIVITY
Sequencing by Synthesis
Single-molecule Sequencing
Nanopore Sequencing
Polony Sequencing
Nucleotide Modifications and Analogs
DNA Polymerases
Paired-end Inventions
Other Methods
PATENT POSITION OF SEQUENCING COMPETITORS
FIGURE 43 SEQUENCING-RELATED PATENTS, BY COMPANY (NUMBER OF PATENTS)
TECHNOLOGY DISTRIBUTION OF NEXT-GENERATION SEQUENCING PATENTS
FIGURE 44 GLOBAL NEXT-GENERATION SEQUENCING PATENTS, BY TECHNOLOGY, 2001-2009
GEOGRAPHICAL DISTRIBUTION OF NEXT-GENERATION SEQUENCING PATENTS
FIGURE 45 GLOBAL NEXT-GENERATION SEQUENCING-RELATED PATENTS, BY GEOGRAPHY, 2000-2009 (NUMBER OF PATENTS)
SEQUENCING LITIGATION STATUS
TABLE 67 SEQUENCING IP LITIGATION STATUS
INTELLECTUAL PROPERTY POSITION OF SELECTED SEQUENCING COMPANIES
LIFE TECHNOLOGIES
LI-COR BIOSCIENCES
HELICOS BIOSCIENCES
ILLUMINA
INTELLIGENT BIO-SYSTEMS
PACIFIC BIOSCIENCES

Chapter-10: COMPANY PROFILES
23ANDME
AFFOMIX CORPORATION
AFFYMETRIX, INC.
AGILENT TECHNOLOGIES, INC.
ARTEMIS HEALTH, INC.
BASE4INNOVATION, LTD.
BECKMAN COULTER
BIO.LOGIS CENTER FOR HUMAN GENETICS
BIONANOMATRIX, INC.
BIOTIQUE SYSTEMS INC.
CALIPER LIFE SCIENCES
COLLABRX, INC.
COMPLETE GENOMICS, INC.
CONEXIO GENOMICS
CORRELAGEN DIAGNOSTICS, INC.
DANAHER MOTION
DECODEME
DELTADOT, LTD.
DNANEXUS, INC.
DNA STAR, INC.
ELECTRONIC BIOSCIENCES
EUROFINS MEDIGENOMIX GMBH
EXPRESSION ANALYSIS, INC.
FASTERIS SA
FEBIT BIOTECH GMBH
FIREBIRD BIOMOLECULAR SCIENCES, LLC
FLUIDIGM CORPORATION
FOUNDATION FOR APPLIED MOLECULAR EVOLUTION
GATC BIOTECH AG
GE HEALTHCARE
GENEDATA AG
GENOME DIAGNOSTICS B.V
GENOMEQUEST, INC.
GENOMATIX SOFTWARE, INC.
GENOVOXX GMBH
GEOSPIZA, INC.
HALCYON MOLECULAR
HELICOS BIOSCIENCES CORPORATION
INTERNATIONAL BUSINESS MACHINES CORP.
ILLUMINA, INC.
TABLE 68 ILLUMINA SEQUENCING TECHNOLOGY SPACE
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
INTELLIGENT BIO-SYSTEMS
INTERNA GENOMICS BV
ION TORRENT SYSTEMS
IP GENESIS INC.
ISENTIO AS
KNOME, INC.
LASERGEN, INC.
LI-COR BIOSCIENCES
LIFE TECHNOLOGIES, INC.
LIFECODEXX
LIGHTSPEED GENOMICS
LINGVITAE AS
MICROCHIP BIOTECHNOLOGIES, INC.
MWG BIOTECH AG
MYCROARRAY.COM
NABSYS, INC.
NAVIGENICS
NETWORK BIOSYSTEMS
NEWGENE, LTD.
NUGEN TECHNOLOGIES, INC.
OLINK GENOMICS AB
OPGEN, INC.
OXFORD NANOPORE TECHNOLOGIES
PACIFIC BIOSCIENCES
POPULATION GENETICS TECHNOLOGIES, LTD.
QUANTALIFE, INC.
RAINDANCE TECHNOLOGIES, INC.
REAL TIME GENOMICS
REVEO INC.
ROCHE LIFE SCIENCES
SEIRAD, INC.
SEQUENOM, INC.
SEQWRIGHT
SHIMADZU SCIENTIFIC INSTRUMENTS
SMARTGENE
SOURCE BIOSCIENCES, PLC.
SORENSON GENOMICS
U.S. GENOMICS
VISIGEN BIOTECHNOLOGIES, INC.
X-PRIZE FOUNDATION
ZS GENETICS