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Skeletal Disease Drug Development Pipeline Review, 2017

骨疾患治療薬開発パイプラインレビュー2017

レポート概要

本レポートは、骨疾患治療薬パイプライン展望の概要を明らかにします。また、骨粗鬆症、閉経後骨粗鬆症および変形性関節症(OA)の開発中治療薬、および薬剤開発に関わる主要企業に関する包括的情報を提供します。

OAは、関節炎の最も一般的な形態の1つであり、軟骨が破壊される慢性的な病気です。OAの症状は、関節の痛みや硬直、活動後に悪化する痛み、骨棘、きしむような感覚を含みます。リスクファクターは、高齢、関節損傷、および肥満です。治療は、手術、NSAIDのような薬剤、および運動です。

骨粗鬆症や骨が薄くなることは、骨を弱め、それどころか骨折を引き起こします。リスクファクターは、高齢、女性、低体重、性ホルモン低下や更年期、喫煙、および一部の治療です。閉経後骨粗鬆症は、骨粗鬆症の最も一般的なサブタイプであり、閉経後の多くの女性に影響を及ぼします。骨粗鬆症の兆候や症状は、椎骨の骨折により引き起こされる背部痛、身長の経時的低下、前屈姿勢、予想以上に簡単に起きる骨折などです。予防や治療には、カルシウム、ビタミンD、運動、および他の骨粗鬆症治療薬が含まれます。

これらパイプラインの規模は、閉経後骨粗鬆症の13製品からOAの116製品にまで及びます。細胞外マトリックス形成蛋白質やインターロイキンなどの幅広いターゲットが研究されていますが、OA内の重要なターゲットはプロスタグランジンG/Hシンターゼ1および2です。同様に、骨粗鬆症および閉経後サブタイプ内では、広範な分子ターゲットが研究されています。最も頻繁に研究されているターゲットは、副甲状腺ホルモン受容体、腫瘍壊死因子リガンドスーパーファミリーメンバー11およびスクレロスチンです。

■調査範囲

  • 骨粗鬆症およびOA治療薬パイプライン内において、最も活発に活動しているのはどの企業でしょうか?
  • 各適応症において、各開発段階で最も優れた薬物療法的アプローチはどれでしょうか?
  • このパイプライン内において、大学や組織は、製薬企業と比較してどの程度重要な役割を果たすでしょうか?
  • 骨粗鬆症およびOA分野において起きた最も重要なR&Dの画期的出来事や、データの公表は何でしょうか?

レポート詳細

目次

GBI Research Report Guidance
Executive Summary
Table of Contents
List of Tables
List of Figures
Introduction
Skeletal Disease Report Coverage
Osteoarthritis - Overview
Osteoporosis - Overview
Post Menopausal Osteoporosis - Overview
Therapeutics Development
Osteoarthritis
Osteoporosis
Post Menopausal Osteoporosis
Therapeutics Assessment
Osteoarthritis
Osteoporosis
Post Menopausal Osteoporosis
Companies Involved in Therapeutics Development
Osteoarthritis
Osteoporosis
Post Menopausal Osteoporosis
Dormant Projects
Osteoarthritis
Osteoporosis
Post Menopausal Osteoporosis
Discontinued Products
Osteoarthritis
Osteoporosis
Post Menopausal Osteoporosis
Product Development Milestones
Osteoarthritis
Osteoporosis
Post Menopausal Osteoporosis
Appendix
Methodology
Coverage
Secondary Research
Primary Research
Expert Panel Validation
Contact Us
Disclaimer

List of Tables
Number of Products under Development for Osteoarthritis
Number of Products under Development by Companies, Osteoarthritis
Number of Products under Development by Universities/Institutes, Osteoarthritis
Products under Development by Companies, Osteoarthritis
Products under Development by Universities/Institutes, Osteoarthritis
Number of Products under Development for Osteoporosis
Number of Products under Development by Companies, Osteoporosis
Number of Products under Development by Universities/Institutes, Osteoporosis
Products under Development by Companies, Osteoporosis
Products under Development by Universities/Institutes, Osteoporosis
Number of Products under Development for Post Menopausal Osteoporosis
Number of Products under Development by Companies, Post Menopausal Osteoporosis
Products under Development by Companies, Post Menopausal Osteoporosis
Number of Products by Stage and Target, Osteoarthritis
Number of Products by Stage and Mechanism of Action, Osteoarthritis
Number of Products by Stage and Route of Administration, Osteoarthritis
Number of Products by Stage and Molecule Type, Osteoarthritis
Number of Products by Stage and Target, Osteoporosis
Number of Products by Stage and Mechanism of Action, Osteoporosis
Number of Products by Stage and Route of Administration, Osteoporosis
Number of Products by Stage and Molecule Type, Osteoporosis
Number of Products by Stage and Target, Post Menopausal Osteoporosis
Number of Products by Stage and Mechanism of Action, Post Menopausal Osteoporosis
Number of Products by Stage and Route of Administration, Post Menopausal Osteoporosis
Number of Products by Stage and Molecule Type, Post Menopausal Osteoporosis
Osteoarthritis - Pipeline by A. Menarini Industrie Farmaceutiche Riunite Srl
Osteoarthritis - Pipeline by AbbVie Inc
Osteoarthritis - Pipeline by Abiogen Pharma SpA
Osteoarthritis - Pipeline by Ablynx NV
Osteoarthritis - Pipeline by Achelios Therapeutics Inc
Osteoarthritis - Pipeline by Addex Therapeutics Ltd
Osteoarthritis - Pipeline by Amgen Inc
Osteoarthritis - Pipeline by Amura Holdings Ltd
Osteoarthritis - Pipeline by Arcarios BV
Osteoarthritis - Pipeline by Asahi Kasei Pharma Corp
Osteoarthritis - Pipeline by Asklepios BioPharmaceutical Inc
Osteoarthritis - Pipeline by Astellas Pharma Inc
Osteoarthritis - Pipeline by Biopharm GmbH
Osteoarthritis - Pipeline by Bone Therapeutics SA
Osteoarthritis - Pipeline by Can-Fite BioPharma Ltd
Osteoarthritis - Pipeline by Cardax Inc
Osteoarthritis - Pipeline by Cellular Biomedicine Group Inc
Osteoarthritis - Pipeline by Cipla Ltd
Osteoarthritis - Pipeline by Corestem Inc
Osteoarthritis - Pipeline by Dong-A Socio Holdings Co Ltd
Osteoarthritis - Pipeline by Evgen Pharma Plc
Osteoarthritis - Pipeline by F. Hoffmann-La Roche Ltd
Osteoarthritis - Pipeline by Galapagos NV
Osteoarthritis - Pipeline by Gemphire Therapeutics Inc
Osteoarthritis - Pipeline by GeneFrontier Corp
Osteoarthritis - Pipeline by Genequine Biotherapeutics GmbH
Osteoarthritis - Pipeline by GlaxoSmithKline Plc
Osteoarthritis - Pipeline by HSRx Group
Osteoarthritis - Pipeline by InKemia IUCT Group SA
Osteoarthritis - Pipeline by International Stem Cell Corp
Osteoarthritis - Pipeline by Jeil Pharmaceutical Co Ltd
Osteoarthritis - Pipeline by Jenrin Discovery Inc
Osteoarthritis - Pipeline by K-Stemcell Co Ltd
Osteoarthritis - Pipeline by Kang Stem Biotech Co Ltd
Osteoarthritis - Pipeline by Levolta Pharmaceuticals Inc
Osteoarthritis - Pipeline by LG Chem, Ltd.
Osteoarthritis - Pipeline by Marina Biotech Inc
Osteoarthritis - Pipeline by Medivir AB
Osteoarthritis - Pipeline by Merck KGaA
Osteoarthritis - Pipeline by Mesoblast Ltd
Osteoarthritis - Pipeline by Mor Research Application Ltd
Osteoarthritis - Pipeline by NicOx SA
Osteoarthritis - Pipeline by Nordic Bioscience A/S
Osteoarthritis - Pipeline by Novartis AG
Osteoarthritis - Pipeline by NovelMed Therapeutics Inc
Osteoarthritis - Pipeline by Omeros Corp
Osteoarthritis - Pipeline by Ono Pharmaceutical Co Ltd
Osteoarthritis - Pipeline by OrthoCyte Corp
Osteoarthritis - Pipeline by Osteologix Holdings Plc
Osteoarthritis - Pipeline by Pfizer Inc
Osteoarthritis - Pipeline by Pharmalink AB
Osteoarthritis - Pipeline by Philogen SpA
Osteoarthritis - Pipeline by PhytoHealth Corp
Osteoarthritis - Pipeline by PLx Pharma Inc
Osteoarthritis - Pipeline by ProteoThera Inc
Osteoarthritis - Pipeline by Regeneus Ltd
Osteoarthritis - Pipeline by Regulaxis SAS
Osteoarthritis - Pipeline by Rottapharm Biotech Srl
Osteoarthritis - Pipeline by Samumed LLC
Osteoarthritis - Pipeline by Seikagaku Corp
Osteoarthritis - Pipeline by Stelis Biopharma Pvt Ltd
Osteoarthritis - Pipeline by Takeda Pharmaceutical Company Ltd
Osteoarthritis - Pipeline by TissueGene Inc
Osteoarthritis - Pipeline by Yooyoung Pharmaceutical Co Ltd
Osteoarthritis - Pipeline by Yuhan Corp
Osteoarthritis - Pipeline by Yungjin Pharm Co Ltd
Osteoarthritis - Pipeline by Zimmer Biomet Holdings Inc
Osteoporosis - Pipeline by Addex Therapeutics Ltd
Osteoporosis - Pipeline by Alize Pharma SAS
Osteoporosis - Pipeline by Alvogen Korea Co Ltd
Osteoporosis - Pipeline by Amgen Inc
Osteoporosis - Pipeline by Amura Holdings Ltd
Osteoporosis - Pipeline by BiologicsMD Inc
Osteoporosis - Pipeline by Bone Biologics Corp
Osteoporosis - Pipeline by Bristol-Myers Squibb Company
Osteoporosis - Pipeline by Cellmid Ltd
Osteoporosis - Pipeline by ChoDang Pharm Co Ltd
Osteoporosis - Pipeline by Chugai Pharmaceutical Co Ltd
Osteoporosis - Pipeline by Corium International Inc
Osteoporosis - Pipeline by Critical Pharmaceuticals Ltd
Osteoporosis - Pipeline by Daiichi Sankyo Company Ltd
Osteoporosis - Pipeline by ElexoPharm GmbH
Osteoporosis - Pipeline by EndoCeutics Inc
Osteoporosis - Pipeline by Entera Bio Ltd
Osteoporosis - Pipeline by Enteris BioPharma Inc
Osteoporosis - Pipeline by Enzo Biochem Inc
Osteoporosis - Pipeline by F. Hoffmann-La Roche Ltd
Osteoporosis - Pipeline by Gador SA
Osteoporosis - Pipeline by GL Pharm Tech Corp
Osteoporosis - Pipeline by Glide Pharmaceutical Technologies Ltd
Osteoporosis - Pipeline by Hanmi Pharmaceuticals Co Ltd
Osteoporosis - Pipeline by Haoma Medica Ltd
Osteoporosis - Pipeline by Immunovo BV
Osteoporosis - Pipeline by Immunwork Inc
Osteoporosis - Pipeline by Intas Pharmaceuticals Ltd
Osteoporosis - Pipeline by Ipsen SA
Osteoporosis - Pipeline by Kaken Pharmaceutical Co Ltd
Osteoporosis - Pipeline by Lead Discovery Center GmbH
Osteoporosis - Pipeline by Ligand Pharmaceuticals Inc
Osteoporosis - Pipeline by Lotus Pharmaceutical Co Ltd
Osteoporosis - Pipeline by Lupin Ltd
Osteoporosis - Pipeline by Merck & Co Inc
Osteoporosis - Pipeline by Mereo Biopharma Group Plc
Osteoporosis - Pipeline by NIBEC
Osteoporosis - Pipeline by Omeros Corp
Osteoporosis - Pipeline by Oncobiologics Inc
Osteoporosis - Pipeline by Osteologix Holdings Plc
Osteoporosis - Pipeline by Paras Biopharmaceuticals Finland Oy
Osteoporosis - Pipeline by Pfenex Inc
Osteoporosis - Pipeline by PhytoHealth Corp
Osteoporosis - Pipeline by R Pharm
Osteoporosis - Pipeline by Ribomic Inc
Osteoporosis - Pipeline by Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd
Osteoporosis - Pipeline by Shin Poong PharmCo Ltd
Osteoporosis - Pipeline by Sinil Pharmaceutical Co Ltd
Osteoporosis - Pipeline by Stelis Biopharma Pvt Ltd
Osteoporosis - Pipeline by Sumitomo Dainippon Pharma Co Ltd
Osteoporosis - Pipeline by Terpenoid Therapeutics Inc
Osteoporosis - Pipeline by TSH Biopharm Corporation Ltd
Osteoporosis - Pipeline by Uni-Bio Science Group Ltd
Osteoporosis - Pipeline by Viking Therapeutics Inc
Osteoporosis - Pipeline by Wroclawskie Centrum Badan EIT+ Sp z oo
Osteoporosis - Pipeline by Yooyoung Pharm Co Ltd
Osteoporosis - Pipeline by Zydus Cadila Healthcare Ltd
Post Menopausal Osteoporosis - Pipeline by Amgen Inc
Post Menopausal Osteoporosis - Pipeline by Enteris BioPharma Inc
Post Menopausal Osteoporosis - Pipeline by Intas Pharmaceuticals Ltd
Post Menopausal Osteoporosis - Pipeline by Ipsen SA
Post Menopausal Osteoporosis - Pipeline by Ligand Pharmaceuticals Inc
Post Menopausal Osteoporosis - Pipeline by Lupin Ltd
Post Menopausal Osteoporosis - Pipeline by NIBEC
Post Menopausal Osteoporosis - Pipeline by Oncobiologics Inc
Post Menopausal Osteoporosis - Pipeline by Paras Biopharmaceuticals Finland Oy
Osteoarthritis - Dormant Projects
Osteoporosis - Dormant Projects
Post Menopausal Osteoporosis - Dormant Projects
Osteoarthritis - Discontinued Products
Osteoporosis - Discontinued Products
Post Menopausal Osteoporosis - Discontinued Products

List of Figures
Number of Products under Development for Osteoarthritis
Number of Products under Development by Companies, Osteoarthritis
Number of Products under Development by Universities/Institutes, Osteoarthritis
Number of Products under Development for Osteoporosis
Number of Products under Development by Companies, Osteoporosis
Number of Products under Development by Universities/Institutes, Osteoporosis
Number of Products under Development for Post Menopausal Osteoporosis
Number of Products under Development by Companies, Post Menopausal Osteoporosis
Number of Products by Top 10 Targets, Osteoarthritis
Number of Products by Stage and Top 10 Targets, Osteoarthritis
Number of Products by Top 10 Mechanism of Actions, Osteoarthritis
Number of Products by Stage and Top 10 Mechanism of Actions, Osteoarthritis
Number of Products by Routes of Administration, Osteoarthritis
Number of Products by Stage and Routes of Administration, Osteoarthritis
Number of Products by Top 10 Molecule Types, Osteoarthritis
Number of Products by Stage and Top 10 Molecule Types, Osteoarthritis
Number of Products by Top 10 Targets, Osteoporosis
Number of Products by Stage and Top 10 Targets, Osteoporosis
Number of Products by Top 10 Mechanism of Actions, Osteoporosis
Number of Products by Stage and Top 10 Mechanism of Actions, Osteoporosis
Number of Products by Top 10 Routes of Administration, Osteoporosis
Number of Products by Stage and Top 10 Routes of Administration, Osteoporosis
Number of Products by Top 10 Molecule Types, Osteoporosis
Number of Products by Stage and Top 10 Molecule Types, Osteoporosis
Number of Products by Targets, Post Menopausal Osteoporosis
Number of Products by Stage and Targets, Post Menopausal Osteoporosis
Number of Products by Mechanism of Actions, Post Menopausal Osteoporosis
Number of Products by Stage and Mechanism of Actions, Post Menopausal Osteoporosis
Number of Products by Routes of Administration, Post Menopausal Osteoporosis
Number of Products by Stage and Routes of Administration, Post Menopausal Osteoporosis
Number of Products by Molecule Types, Post Menopausal Osteoporosis
Number of Products by Stage and Molecule Types, Post Menopausal Osteoporosis

発刊日

2017/07/01

体裁

PDF / 176ページ

販売価格

3,995USD

発行

GBI Research

備考

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