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'outline' => '<p>【 刊行にあたって 】</p>
<p>
抗体薬物複合体の開発はMilsteinとKohlerのハイブリドーマ法の開発に端を発し、1970年代から行われており、当初はミサイル治療と呼ばれ、大変期待されたが、マウス抗体であったこと、抗腫瘍剤と抗体を結合するリンカーテクノロジーが未熟であったことなどから、臨床応用されることはなかった。その後、抗体工学の進歩により、キメラ抗体、ヒト化抗体、完全ヒト抗体などの作製技術が確立したことに加え、リンカーテクノロジーの進歩もあり、ADCは血液系腫瘍を対象として臨床開発が進んでいたが、2013年にTDM-1が転移性乳がんにFDAにより承認され、ADCの一般固形がんに対するはじめての本格的参入ということで、大きなインパクトを与えた。実際、2015年のアメリカ腫瘍学会（ASCO）におけるFDAの発表によると、現在のADCの治験は優に50を越える数にのぼっている。最も、そのほとんどが、アメリカ発のADCとなっており、ADCにおいても、日本はアメリカにほぼ完全に負けている。このままでは、さらに医薬品の輸入超過に拍車を掛けることになるであろう。
</p>
<p>
このような状況下で、色んなパーツの複合体といえるADCの本邦における成功をめざし、アカデミアと産業界から、それぞれの分野の第一線の研究者の方々に執筆していただいた。本書が、ADCに興味をもっていただくための参考書となることを祈念している。
</p>
<p>（本書「はじめに」より一部抜粋）</p>
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<p>
2013年に「ブロック共重合体の自己組織化技術の基礎と応用」(以下「ブロック」)というタイトルでブロック共重合体の自己組織化によって形成されるモルフォロジーとその応用に関して、基礎的な部分から最新情報も含めた知見をこの分野の第一人者の諸先生方に執筆をお願いして、体系的にまとめたものを出版した。この当時、ブロック共重合体の自己組織化によって形成されるボトムアップ型の長距離秩序を持ったナノ構造は、ナノテクノロジーへの応用の期待されていたため、2012年におけるブロック共重合体関連の論文数は3700報にも上っており、その関心の高さもあって、「ブロック」も好評であった。<br />
「ブロック」を出版して以来5年がたつが、昨年1年間でのブロック共重合体関連の論文数は2012年からさらに増えて4500報になっており、ブロック共重合体に対する注目度はいまだに高い。<br />
その様な状況を鑑みて、「ブロック」に続くものとしてこの本の企画がなされた。この本においては、ブロック共重合体の形成する準結晶や、反射率測定など新しい物理・解析法、様々なブロック共重合体の新規合成法、新しいブロック共重合体の応用など、「ブロック」以降の新しい展開を網羅している。この本が「ブロック」同様、大学、研究機関、企業でのブロック共重合体の研究・開発に従事されていらっしゃる方のお役に立てれば幸いである。<br />
(本書「はじめに」より一部抜粋)
</p>
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世界のビタミンA市場:分析:タイプ別(天然および合成)、製品別(飼料グレード、食品グレード、医薬品グレード)、用途別(動物飼料、医薬品/栄養補助食品、食品および飲料、化粧品)、地域規模別、COVID-19の影響を伴う動向、および2029年までの予測
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ビタミンAとは、視力、免疫機能、皮膚の健康など、さまざまな身体機能に不可欠な脂溶性化合物のグループを指します。動物性食品に含まれるレチノイドと、植物性食品に含まれるカロテノイドの両方が含まれます。ビタミンAは、健康な視力を維持し、細胞の成長と分化をサポートし、免疫機能を強化するために重要です。欠乏症は視力障害、免疫機能の低下、皮膚障害につながる可能性があるため、全体的な健康と幸福に不可欠な栄養素です。世界のビタミンA市場の価値は2023年に5億4,836万ドルに達し、2029年には7億4,584万ドルに達する見込みです。
</p>
<p>
世界のビタミンA市場の継続的な成長は、いくつかの重要な要因に起因します。第一に、世界的な老年人口の増加は、高齢者が追加の栄養サポートを必要とすることが多いため、ビタミンAの需要の増加に大きく貢献しています。第二に、農業における飼料強化の実践の成長により、家畜のビタミンAの消費量が増加し、間接的に動物性食品を介したヒトの摂取量が増加しています。さらに、肌の健康に対する意識の高まりにより、スキンケア製品への消費者支出が増加していることから、局所製剤におけるビタミンAの需要が高まっています。さらに、栄養補助食品産業の拡大により、消費者はビタミンAサプリメントに簡単にアクセスできるようになりました。ビタミンAなどの必須栄養素で強化された機能性食品の需要の高まりも、市場の成長に寄与しています。さらに、眼や皮膚の疾患の急増やビタミンA欠乏症の蔓延により、十分なビタミンA摂取の重要性が強調され、市場拡大がさらに促進されています。市場は、2024年から2029年の予測期間にわたって5.26%のCAGRで成長すると予想されます。
</p>
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View::_render() - CORE/Cake/View/View.php, line 933
View::render() - CORE/Cake/View/View.php, line 473
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